{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:23:59Z","timestamp":1792009439246,"version":"4.4.0"},"reference-count":142,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T00:00:00Z","timestamp":1487289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The inherited bone marrow failure syndromes (<jats:styled-content style=\"fixed-case\">IBMFS<\/jats:styled-content>) typically present with significant cytopenias in at least one haematopoietic cell lineage that may progress to pancytopenia, and are associated with increased risk of cancer. Although the clinical features of the <jats:styled-content style=\"fixed-case\">IBMFS<\/jats:styled-content> are often diagnostic, variable disease penetrance and expressivity may result in diagnostic dilemmas. The discovery of the genetic aetiology of the <jats:styled-content style=\"fixed-case\">IBMFS<\/jats:styled-content> has been greatly facilitated by next\u2010generation sequencing methods. This has advanced understanding of the underlying biology of the <jats:styled-content style=\"fixed-case\">IBMFS<\/jats:styled-content> and been essential in improving clinical management and genetic counselling for affected patients. Herein we review the clinical features, underlying biology, and new genomic discoveries in the <jats:styled-content style=\"fixed-case\">IBMFS<\/jats:styled-content>, including Fanconi anaemia, dyskeratosis congenita, Diamond Blackfan anaemia, Shwachman Diamond syndrome and some disorders of the myeloid and megakaryocytic lineages.<\/jats:p>","DOI":"10.1111\/bjh.14535","type":"journal-article","created":{"date-parts":[[2017,2,17]],"date-time":"2017-02-17T12:12:46Z","timestamp":1487333566000},"page":"526-542","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":97,"title":["The genomics of inherited bone marrow failure: from mechanism to the clinic"],"prefix":"10.1111","volume":"177","author":[{"given":"Talia","family":"Wegman\u2010Ostrosky","sequence":"first","affiliation":[{"name":"Clinical Genetics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"},{"name":"Research Division Instituto Nacional de Cancerologia Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon A.","family":"Savage","sequence":"additional","affiliation":[{"name":"Clinical Genetics Branch Division of Cancer Epidemiology and Genetics National Cancer Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1083"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22397"},{"key":"e_1_2_13_4_1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1159\/000346035","article-title":"VACTERL\u2010H association and Fanconi anemia","volume":"4","author":"Alter B.P.","year":"2013","journal-title":"Molecular Syndromology"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-02-075598"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08212.x"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.055269"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9829"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.1084"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2009.01.013"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI33764"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergen.2015.01.007"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.13.23"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1003695"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1265-8"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1291377"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.1.139"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-234120"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2015.1094596"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-07-1501"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-324541"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88010"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1062"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.05.005"},{"key":"e_1_2_13_25_1","first-page":"335","article-title":"Acute lymphoidic leukemia in a patient with thrombocytopenia\/absent radii (Tar) syndrome","volume":"15","author":"Camitta B.M.","year":"1993","journal-title":"The American Journal of Pediatric Hematology\/Oncology"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.025130"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-474585"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.04.009"},{"key":"e_1_2_13_29_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Clinton C.","year":"2009"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12502"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13317"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-43552"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12097"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.020529"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.015495"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3088"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1300600110"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2014.170"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0421"},{"key":"e_1_2_13_40_1","doi-asserted-by":"crossref","first-page":"3048","DOI":"10.1182\/blood.V94.9.3048","article-title":"Shwachman\u2010Diamond syndrome: an inherited preleukemic bone marrow failure disorder with aberrant hematopoietic progenitors and faulty marrow microenvironment","volume":"94","author":"Dror Y.","year":"1999","journal-title":"Blood"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.20327"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12167"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-02-140012"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-375170"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.100"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.623011"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-727891"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.22680"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes5041064"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-015-0024-z"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-09-427740"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.22927"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1751-553X.2012.01454.x"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmedgenet-2015-103270"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312153092404"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13442"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00054.x"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2013.73"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051609898"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36633"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-08-596445"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/gim.2014.147"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/345458a0"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0598-32"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.04.022"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000126"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw005"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.6.2156.bloodjournal8662156"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.01.004"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.04.007"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminhematol.2013.09.002"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000441"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01690.x"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.248567.114"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-05-574889"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-013-1326-z"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt178"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.01.004"},{"key":"e_1_2_13_79_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1159\/000484749","article-title":"Somatic mosaicism in Fanconi anemia: molecular basis and clinical significance","volume":"5","author":"Lo Ten Foe J.R.","year":"1997","journal-title":"European Journal of Human Genetics"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-016-2218-x"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.01.011"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes7090064"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1829"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1458"},{"key":"e_1_2_13_85_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Mehta P.A.","year":"2002"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-11-540278"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/990141"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-genet-102108-134222"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1002\/em.21938"},{"key":"e_1_2_13_90_1","volume-title":"GeneReviews\u00ae [Internet]","author":"Myers K.","year":"2008"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.4137\/CMBD.S16952"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12516"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.10.010"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2009.12.039"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2016.05.009"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2848"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.genet.41.110306.130350"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24552"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.29.9.673"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2016.04.002"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.09.009"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12976-015-0011-4"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.34087"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI63597"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2206"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2007.10.004"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.37461"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2010.03.002"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20151618"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.1586\/ehm.12.48"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-05-1852"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.31421"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaf7837"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0b013e318158152e"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000587"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0098686"},{"key":"e_1_2_13_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3278"},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.276873.115"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2009.018119"},{"key":"e_1_2_13_120_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/asheducation-2015.1.1","article-title":"Game of clones: the genomic evolution of severe congenital neutropenia","volume":"2015","author":"Touw I.P.","year":"2015","journal-title":"Hematology\/the Education Program of the American Society of Hematology"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.01.007"},{"key":"e_1_2_13_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2016.05.002"},{"key":"e_1_2_13_123_1","doi-asserted-by":"crossref","first-page":"4034","DOI":"10.1182\/blood.V86.11.4034.bloodjournal86114034","article-title":"Carrier frequency of the IVS4\u00a0+\u00a04 A\u2013>T mutation of the Fanconi anemia gene FAC in the Ashkenazi Jewish population","volume":"86","author":"Verlander P.C.","year":"1995","journal-title":"Blood"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2008.07269.x"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2004.12.008"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2622"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0800042105"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0b013e328314b651"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm111"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2011.052787"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.02.001"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.147769"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.07.009"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2009.01.013"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm3031018"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2016.03.04"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24545"},{"key":"e_1_2_13_138_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-01-0335"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa042980"},{"key":"e_1_2_13_140_1","doi-asserted-by":"publisher","DOI":"10.1080\/21675511.2015.1025185"},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414799"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2015.1037756"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10897-014-9754-z"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14535","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14535","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:51:52Z","timestamp":1696315912000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14535"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,17]]},"references-count":142,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/bjh.14535"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14535","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,17]]},"assertion":[{"value":"2016-10-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-11-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}