{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T13:18:46Z","timestamp":1758892726124},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001646","name":"Robert Bosch Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Imbalances in the composition of BCL2 family proteins contribute to tumourigenesis and therapy resistance of mantle cell lymphoma (<jats:styled-content style=\"fixed-case\">MCL<\/jats:styled-content>), making these proteins attractive therapy targets. We studied the efficiency of dual targeting the NOXA\/MCL1 axis by combining fatty acid synthase inhibitors (NOXA stabilization) with the CDK inhibitor Dinaciclib (MCL1 reduction). This combination synergistically induced apoptosis in cell lines and primary MCL cells and led to almost complete inhibition of tumour progression in a mouse model. Apoptosis was NOXA\u2010dependent and correlated with the NOXA\/MCL1 ratio, highlighting the importance of the NOXA\/MCL1 balance for effective cell death induction in MCL.<\/jats:p>","DOI":"10.1111\/bjh.14571","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T21:22:43Z","timestamp":1489526563000},"page":"557-561","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dual targeting of MCL1 and NOXA as effective strategy for treatment of mantle cell lymphoma"],"prefix":"10.1111","volume":"177","author":[{"given":"Elisabeth","family":"H\u00f6ring","sequence":"first","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology and University of Tuebingen Stuttgart Germany"},{"name":"Department of Haematology and Oncology Robert\u2010Bosch\u2010Hospital Stuttgart Germany"},{"name":"Haematopathology Unit Hospital Cl\u00ednic \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arnau","family":"Montraveta","sequence":"additional","affiliation":[{"name":"Haematopathology Unit Hospital Cl\u00ednic \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Heine","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology and University of Tuebingen Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Kleih","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology and University of Tuebingen Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Schaaf","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology and University of Tuebingen Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias C.","family":"V\u00f6hringer","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Robert\u2010Bosch\u2010Hospital Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Esteve\u2010Arenys","sequence":"additional","affiliation":[{"name":"Haematopathology Unit Hospital Cl\u00ednic \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gael","family":"Rou\u00e9","sequence":"additional","affiliation":[{"name":"Haematopathology Unit Hospital Cl\u00ednic \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[{"name":"Haematopathology Unit Hospital Cl\u00ednic \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Campo","sequence":"additional","affiliation":[{"name":"Haematopathology Unit Hospital Cl\u00ednic \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Hospital Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walter E.","family":"Aulitzky","sequence":"additional","affiliation":[{"name":"Department of Haematology and Oncology Robert\u2010Bosch\u2010Hospital Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiko","family":"van der Kuip","sequence":"additional","affiliation":[{"name":"Dr. Margarete Fischer\u2010Bosch\u2010Institute of Clinical Pharmacology and University of Tuebingen Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-15-1070"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1517\/13543784.2013.789859"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3578"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.552"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2014.119115"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601911417177"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.31"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.10"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.5b00447"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23568"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-07-034173"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2009.46"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1210679"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2015.08.009"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2015.05.014"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14571","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14571","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T06:52:05Z","timestamp":1696315925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":15,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["10.1111\/bjh.14571"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14571","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"2016-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2016-12-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}