{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:25:56Z","timestamp":1792797956789,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T00:00:00Z","timestamp":1488931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Blood Transfusion Service Z\u00fcrich"},{"name":"Swiss Red Cross (SRC)","id":[{"id":"https:\/\/ror.org\/047pm4955","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Z\u00fcrich-Schlieren, Switzerland"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GYPC<\/jats:styled-content>\n                    <\/jats:italic>\n                    gene encodes the glycophorins C and D. The two moieties express 12 known antigens of the Gerbich blood group system and functionally stabilize red blood cell membranes through their intracellular interaction with protein 4.1 and p55. Three\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GYPC<\/jats:styled-content>\n                    <\/jats:italic>\n                    exon deletions are responsible for the lack of the high\u2010frequency antigens Ge2 (Yus type, exon 2 deletion), Ge2 and Ge3 (Gerbich type, exon 3 deletion), and Ge2 to 4 (Leach type, exons 3 and 4 deletion), but lack exact molecular description.\u00a0A total of 29 rare blood samples with Yus (\n                    <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>\n                    :\u20102,3,4) and Gerbich (\n                    <jats:styled-content style=\"fixed-case\">GE<\/jats:styled-content>\n                    :\u20102,\u20103,4) phenotypes, including individuals of Middle\u2010Eastern, North\u2010African or Balkan ancestry were examined genetically. All phenotypes could be explained by 4 different Yus alleles, characterized by deletions of exon 2 and adjacent introns, and 3 different Gerbich alleles, with deletions of exon 3 and adjacent introns. A 3600 base pair\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">GYPC<\/jats:styled-content>\n                    <\/jats:italic>\n                    region, encompassing exon 2 and flanking region, shares a high degree of sequence homology with a region flanking exon 3, probably representing an evolutionary duplication event. Defining the expression of Gerbich variants presently relies on rare serological reagents. Our approach substitutes the serological characterization with a precise genotype approach to identify the rare Yus and Gerbich alleles.\n                  <\/jats:p>","DOI":"10.1111\/bjh.14578","type":"journal-article","created":{"date-parts":[[2017,3,8]],"date-time":"2017-03-08T07:02:56Z","timestamp":1488956576000},"page":"630-640","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Genetic background of the rare Yus and Gerbich blood group phenotypes: homologous regions of the\n                    <i>\n                      <scp>GYPC<\/scp>\n                    <\/i>\n                    gene contribute to deletion alleles"],"prefix":"10.1111","volume":"177","author":[{"given":"Elise","family":"Gourri","sequence":"first","affiliation":[{"name":"Department of Molecular Diagnostics and Research &amp; Development Blood Transfusion Service Z\u00fcrich Swiss Red Cross (SRC) Z\u00fcrich\u2010Schlieren Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A.","family":"Denomme","sequence":"additional","affiliation":[{"name":"Diagnostic Laboratories and Blood Research Institute Blood Center of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Merki","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics and Research &amp; Development Blood Transfusion Service Z\u00fcrich Swiss Red Cross (SRC) Z\u00fcrich\u2010Schlieren Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erwin A.","family":"Scharberg","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine and Immunohematology, Baden\u2010Baden German Red Cross Blood Service Baden\u2010W\u00fcrttemberg \u2010 Hessen Baden\u2010Baden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cedric","family":"Vrignaud","sequence":"additional","affiliation":[{"name":"D\u00e9partement Centre National de R\u00e9f\u00e9rence pour les Groupes Sanguins Institut National de la Transfusion Sanguine (INTS) Paris France"},{"name":"Inserm UMR_S1134 Paris France"},{"name":"Laboratoire d'Excellence GR\u2010Ex Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beat M.","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Molecular Diagnostics and Research &amp; 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