{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T02:54:25Z","timestamp":1792119265016,"version":"4.4.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T00:00:00Z","timestamp":1489449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["WT093727MA"],"award-info":[{"award-number":["WT093727MA"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Sickle cell disease (\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    ) is the single most important genetic cause of childhood mortality globally. Tanzania has one of the highest annual births of\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    individuals in the world, estimated to reach 11\u00a0000 births a year. Without intervention, 50\u201390% of children will die in childhood. However, cost\u2010effective interventions have the potential to reduce childhood mortality by up to 70%. The effects of\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    are multi\u2010dimensional, ranging from causing high morbidity and mortality, and reducing the quality of life, to imposing a high socio\u2010economic burden on individuals, families and health systems. In the past 12\u00a0years, the\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    programme in Tanzania has developed, with local and global partnerships, a systematic framework for comprehensive research that is integrated into providing healthcare, training and advocacy in\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    . This report outlines the approach and achievements of collective initiatives for management and control of\n                    <jats:styled-content style=\"fixed-case\">SCD<\/jats:styled-content>\n                    in Tanzania.\n                  <\/jats:p>","DOI":"10.1111\/bjh.14594","type":"journal-article","created":{"date-parts":[[2017,3,14]],"date-time":"2017-03-14T17:23:18Z","timestamp":1489512198000},"page":"919-929","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":79,"title":["Sickle cell disease in Africa: an overview of the integrated approach to health, research, education and advocacy in Tanzania, 2004\u20132016"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3130-3616","authenticated-orcid":false,"given":"Furahini","family":"Tluway","sequence":"first","affiliation":[{"name":"Sickle Cell Programme Department of Haematology and Blood Transfusion Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Makani","sequence":"additional","affiliation":[{"name":"Sickle Cell Programme Department of Haematology and Blood Transfusion Muhimbili University of Health and Allied Sciences Dar es Salaam Tanzania"},{"name":"Nuffield Department of Medicine University of Oxford Oxford United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,3,14]]},"reference":[{"key":"e_1_2_12_2_1","first-page":"102","article-title":"Septicaemia in sickle cell anaemia patients: the Ibadan experience","volume":"44","author":"Aken'ova Y.A.","year":"1998","journal-title":"The Central African Journal of Medicine"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963662514547478"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0000234"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2009.03.010"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"2555","DOI":"10.1182\/blood.V79.10.2555.2555","article-title":"Hydroxyurea: effects on haemoglobin F production in patients with sickle cell anaemia","volume":"79","author":"Charache S.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198606193142501"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.2.776.bloodjournal862776"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.013"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251546"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/516781"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.388"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.2005.088807"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109709"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1086\/599834"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.84.3.500"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-07-233528"},{"key":"e_1_2_12_18_1","first-page":"1390","article-title":"Genetics of foetal hemoglobin in Tanzanian and British patients with sickle cell anaemia","volume":"27","author":"Makani J.","year":"2010","journal-title":"Blood"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0014699"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13553"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-265249"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/ahg.12077"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0125929"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0111464"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12881-015-0148-3"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23859"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.196295.115"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60193-6"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02267.x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/1478-4505-9-S1-S7"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001484"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1043454204265841"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2009.07650.x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.285.6342.633"},{"key":"e_1_2_12_35_1","unstructured":"United Nations General Assembly Resolution. (2009)Sickle Cell Anaemia as a public health problem. Resolution 63\/237. Available at:https:\/\/www.un.org\/sg\/en\/content\/sg\/statement\/2009-06-19\/secretary-generals-message-sickle-cell-anaemia"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-251348"},{"key":"e_1_2_12_37_1","volume-title":"Management of Birth Defects and Haemoglobin Disorders: Report of a Joint WHO\u2010March of Dimes Meeting","author":"WHO","year":"2006"},{"key":"e_1_2_12_38_1","unstructured":"WHO. (2010)Sickle Cell Disease: A Strategy For The WHO Africa Region. Report of the Regional Director. Document number AFR\/RC60\/8.Geneva Switzerland:World Health Organization Regional Office for Africa."},{"key":"e_1_2_12_39_1","unstructured":"WHO. (2011)Uniting against NCDs: the time to act is now. The Brazzaville declaration on Non\u2010communicable diseases prevention and control in the WHO African region.Geneva Switzerland:World Health Organization Regional Office for Africa."},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61374-X"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14594","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14594","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T13:07:58Z","timestamp":1694524078000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,14]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/bjh.14594"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14594","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,14]]},"assertion":[{"value":"2017-03-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}