{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T02:34:58Z","timestamp":1785551698637,"version":"3.56.0"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T00:00:00Z","timestamp":1490659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Atypical chronic myeloid leukaemia (<jats:styled-content style=\"fixed-case\">aCML<\/jats:styled-content>) is an aggressive malignancy for which allogeneic haematopoietic stem cell transplantation (allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>) represents the only curative option. We describe transplant outcomes in 42 patients reported to the European Society for Blood and Marrow Transplantation (<jats:styled-content style=\"fixed-case\">EBMT<\/jats:styled-content>) registry who underwent allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> for <jats:styled-content style=\"fixed-case\">aCML<\/jats:styled-content> between 1997 and 2006. Median age was 46\u00a0years. Median time from diagnosis to transplant was 7\u00a0months. Disease status was first chronic phase in 69%. Donors were human leucocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>)\u2010identical siblings in 64% and matched unrelated (<jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content>) in 36%. A reduced intensity conditioning was employed in 24% of patients. T\u2010cell depletion was applied in 87% and 26% of transplants from <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010identical siblings, respectively. According to the <jats:styled-content style=\"fixed-case\">EBMT<\/jats:styled-content> risk\u2010score, 45% of patients were \u2018low\u2010risk\u2019, 31% \u2018intermediate\u2010risk\u2019 and 24% \u2018high\u2010risk\u2019. Following allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, 87% of patients achieved complete remission. At 5\u00a0years, relapse\u2010free survival was 36% and non\u2010relapse mortality (<jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content>) was 24%, while relapse occurred in 40%. Patient age and the <jats:styled-content style=\"fixed-case\">EBMT<\/jats:styled-content> score had an impact on overall survival. Relapse\u2010free survival was higher in <jats:styled-content style=\"fixed-case\">MUD<\/jats:styled-content> than in <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>\u2010identical sibling <jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content>, with no difference in <jats:styled-content style=\"fixed-case\">NRM<\/jats:styled-content>. In conclusion, this study confirmed that allo\u2010<jats:styled-content style=\"fixed-case\">HSCT<\/jats:styled-content> represents a valid strategy to achieve cure in a reasonable proportion of patients with <jats:styled-content style=\"fixed-case\">aCML<\/jats:styled-content>, with young patients with low <jats:styled-content style=\"fixed-case\">EBMT<\/jats:styled-content> risk score being the best candidates.<\/jats:p>","DOI":"10.1111\/bjh.14619","type":"journal-article","created":{"date-parts":[[2017,3,28]],"date-time":"2017-03-28T11:55:00Z","timestamp":1490702100000},"page":"759-765","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Allogeneic stem cell transplantation in patients with atypical chronic myeloid leukaemia: a retrospective study from the Chronic Malignancies Working Party of the European Society for Blood and Marrow Transplantation"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2991-3474","authenticated-orcid":false,"given":"Francesco","family":"Onida","sequence":"first","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico University of Milan Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth C.","family":"de Wreede","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics &amp; Bioinformatics Leiden University Medical Centre Leiden The Netherlands"},{"name":"DKMS Clinical Trials Unit Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"van Biezen","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics &amp; Bioinformatics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diderik\u2010Jan","family":"Eikema","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics &amp; Bioinformatics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny L.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Nottingham University Hospitals Trust Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna P.","family":"Iori","sequence":"additional","affiliation":[{"name":"Azienda Policlinico Umberto I \u2018La Sapienza\u2019 University Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rik","family":"Schots","sequence":"additional","affiliation":[{"name":"Universitair Ziekenhuis Brussel Brussels 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