{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T12:16:34Z","timestamp":1780575394414,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T00:00:00Z","timestamp":1493942400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Vascular and non\u2010vascular complications are common in patients with polycythaemia vera. This retrospective study of 217 patients with polycythaemia vera aimed to determine whether blood counts with respect to different treatments influenced the complication rate and survival. We found that 78 (36%) patients suffered from at least one complication during follow\u2010up. Older age and elevated lactate dehydrogenase at diagnosis were found to be risk factors for vascular complications. When the vascular complication occurred, 41% of the patients with a complication had elevated white blood cells (<jats:styled-content style=\"fixed-case\">WBC<\/jats:styled-content>) compared with 20% of patients without a complication (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7042). Patients treated with hydroxycarbamide (<jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>; also termed hydroxyurea) experienced significantly fewer vascular complications (11%) than patients treated with phlebotomy only (27%) (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013). We also found a survival advantage for patients treated with <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>, when adjusted for age, gender and time period of diagnosis (Hazard ratio for phlebotomy\u2010treated patients compared to <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010treated patients at 5\u00a0years was 2\u00b742, 95% confidence interval 1\u00b703\u20105\u00b772, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7043). Concerning survival and vascular complications, <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010treated patients who needed at least one phlebotomy per year were not significantly different from <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010treated patients with a low phlebotomy requirement. We conclude that complementary phlebotomy in <jats:styled-content style=\"fixed-case\">HC<\/jats:styled-content>\u2010treated patients in order to maintain the haematocrit, is safe.<\/jats:p>","DOI":"10.1111\/bjh.14625","type":"journal-article","created":{"date-parts":[[2017,5,5]],"date-time":"2017-05-05T05:16:41Z","timestamp":1493961401000},"page":"800-805","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A retrospective analysis of the impact of treatments and blood counts on survival and the risk of vascular events during the course of polycythaemia vera"],"prefix":"10.1111","volume":"177","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9984-3520","authenticated-orcid":false,"given":"Anneli","family":"Enblom\u2010Larsson","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Sunderby hospital Lule\u00e5 Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3151-1068","authenticated-orcid":false,"given":"Francois","family":"Girodon","sequence":"additional","affiliation":[{"name":"Service d'h\u00e9matologie Biologique CHU de Dijon Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Bak","sequence":"additional","affiliation":[{"name":"Department of Hematology Roskilde hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Hersby","sequence":"additional","affiliation":[{"name":"Department of Hematology Roskilde hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Jooste","sequence":"additional","affiliation":[{"name":"Registre Bourguignon des Cancers Digestifs INSERM UMR 866 \u2010 CHU Dijon Bourgogne \u2010 Universit\u00e9 Bourgogne Franche\u2010Comt\u00e9 Dijon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Hasselbalch","sequence":"additional","affiliation":[{"name":"Department of Hematology Roskilde hospital Roskilde Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Johansson","sequence":"additional","affiliation":[{"name":"Hematology and Coagulation section Department of Medicine Sahlgrenska University Hospital Gothenburg Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Andreasson","sequence":"additional","affiliation":[{"name":"NU hospital group Uddevalla Hospital Uddevalla Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2010.01548.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.152769"},{"key":"e_1_2_7_4_1","unstructured":"Andersen C.L. Andreasson B. Hasselbalch H. Hultcrantz M. Knutsen H. Lindgren M. Skjelbakken T. Samuelsson J.&Larsen T.S.;for the Nordic MPN Group. (2013)Nordic guidelines on the diagnosis and treatment of patients with Myeloproliferative Neoplasms. WWW document. URL:http:\/\/nmpn.org\/index.php\/guidelines\/1-nmpn-guidelines-2013\/file. 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