{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T02:17:19Z","timestamp":1792289839445,"version":"4.4.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Interferon\u2010based regimens for chronic hepatitis C (<jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>) were often deferred in patients with \u03b2\u2010thalasaemia major (\u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content>) due to poor efficacy and tolerance. Current guidelines recommend direct\u2010acting antivirals (<jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s) for these patients. The aim of this study was to assess the safety and efficacy of <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s in patients with \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and advanced liver disease due to <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content>. Patients were recruited from eight liver units in Greece. The stage of liver disease was assessed using transient elastography and\/or liver histology. Five regimens were used: sofosbuvir (<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content>)\u00a0+\u00a0ribavirin (<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>);\u00a0<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content>\u00a0+\u00a0simeprevir\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>;<jats:styled-content style=\"fixed-case\"> SOF<\/jats:styled-content>\u00a0+\u00a0daclatasvir\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>; ledipasvir\/<jats:styled-content style=\"fixed-case\">SOF<\/jats:styled-content>\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content> and ombitasvir\/paritaprevir\u2010ritonavir\u00a0+\u00a0dasabuvir\u00a0\u00b1\u00a0<jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content>. Sixty\u2010one patients (median age 43\u00a0years) were included. The majority of patients was previously treated for hepatitis C (75%) and had cirrhosis (79%). Viral genotype distribution was: G1a: <jats:italic>n<\/jats:italic>\u00a0=\u00a010 (16%); G1b: <jats:italic>n<\/jats:italic>\u00a0=\u00a022 (36%); G2: <jats:italic>n<\/jats:italic>\u00a0=\u00a02 (3%); G3: <jats:italic>n<\/jats:italic>\u00a0=\u00a014 (23%); G4: <jats:italic>n<\/jats:italic>\u00a0=\u00a013 (22%). The predominant chelation therapy was a combination of deferoxamine and deferiprone (35%). Overall sustained virological response rates were 90%. All treatment regimens were well tolerated and no major adverse events or drug\u2010drug interactions were observed. Approximately half of the patients who received <jats:styled-content style=\"fixed-case\">RBV<\/jats:styled-content> (7\/16, 44%) had increased needs for blood transfusion. Treatment of <jats:styled-content style=\"fixed-case\">CHC<\/jats:styled-content> with <jats:styled-content style=\"fixed-case\">DAA<\/jats:styled-content>s in patients with \u03b2\u2010<jats:styled-content style=\"fixed-case\">TM<\/jats:styled-content> and advanced liver disease was highly effective and safe.<\/jats:p>","DOI":"10.1111\/bjh.14640","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T08:59:02Z","timestamp":1493110742000},"page":"130-136","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Treatment of chronic hepatitis C with direct\u2010acting antivirals in patients with \u03b2\u2010thalassaemia major and advanced liver disease"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0923-050X","authenticated-orcid":false,"given":"Emmanouil","family":"Sinakos","sequence":"first","affiliation":[{"name":"4th Medical Department Aristotle 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