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We examined the clinical utility of high\u2010resolution telomere length analysis as a prognostic marker in <jats:styled-content style=\"fixed-case\">MM<\/jats:styled-content>. Cohort stratification, using a previously determined length threshold for telomere dysfunction, revealed that patients with short telomeres had a significantly shorter overall survival (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001; <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u00a0=\u00a03\u00b74). Multivariate modelling using forward selection identified International Staging System (<jats:styled-content style=\"fixed-case\">ISS<\/jats:styled-content>) stage as the most important prognostic factor, followed by age and telomere length. Importantly, each <jats:styled-content style=\"fixed-case\">ISS<\/jats:styled-content> prognostic subset could be further risk\u2010stratified according to telomere length, supporting the inclusion of this parameter as a refinement of the <jats:styled-content style=\"fixed-case\">ISS<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.14643","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T09:06:39Z","timestamp":1490432799000},"page":"94-98","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Telomere length is a critical determinant for survival in multiple myeloma"],"prefix":"10.1111","volume":"178","author":[{"given":"Sam","family":"Hyatt","sequence":"first","affiliation":[{"name":"Division of Cancer &amp; Genetics School of Medicine Cardiff University Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhiannon E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Cancer &amp; 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