{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T17:15:25Z","timestamp":1763399725216,"version":"3.37.3"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T00:00:00Z","timestamp":1491523200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K12 CA090628"],"award-info":[{"award-number":["K12 CA090628"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Summary<\/jats:title>CD<\/jats:styled-content>49d is a surface integrin that is expressed on chronic lymphocytic leukaemia (CLL<\/jats:styled-content>) cells, and strongly correlates with more aggressive disease. Given its association with cell\u2010cell adhesion and leucocyte trafficking, we hypothesized that patients with high CD<\/jats:styled-content>49d expression would experience a clinical course dominated by lymphadenopathy. CD<\/jats:styled-content>49d expression was measured by flow cytometry and considered positive if expressed by \u226530% of CLL<\/jats:styled-content> cells. The study included 797 newly diagnosed CLL<\/jats:styled-content>\/small lymphocytic leukaemia patients; 279 (35%) were CD<\/jats:styled-content>49d positive. CD<\/jats:styled-content>49d\u2010positive patients were more likely to present with lymphadenopathy (P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001); a finding that persisted after adjusting for fluorescence in\u00a0situ<\/jats:italic> hybridisation (FISH<\/jats:styled-content>) and IGHV<\/jats:styled-content><\/jats:italic> mutation status [odds ratio (OR<\/jats:styled-content>) 2\u00b751; 95% confidence interval (CI<\/jats:styled-content>) 1\u00b764\u20133\u00b783; P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b7001]. Among CLL<\/jats:styled-content> Rai 0 patients, CD<\/jats:styled-content>49d positivity was associated with shorter time to development of lymphadenopathy (3\u00b72\u00a0years vs not reached, P\u00a0<\/jats:italic><\u00a0<\/jats:italic>0\u00b701). This association was maintained after adjusting for either FISH<\/jats:styled-content> [hazard ratio (HR<\/jats:styled-content>) 2\u00b718; 95% CI<\/jats:styled-content> 1\u00b725\u20133\u00b781; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b7006) or IGHV<\/jats:styled-content><\/jats:italic> status (HR<\/jats:styled-content> 2\u00b702; 95% CI<\/jats:styled-content> 1\u00b711\u20133\u00b769; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b702) individually, but was attenuated when adjusting by both (HR<\/jats:styled-content> 1\u00b772; 95% CI<\/jats:styled-content> 0\u00b788\u20133\u00b738; P\u00a0<\/jats:italic>=\u00a0<\/jats:italic>0\u00b711).These data demonstrate that CD<\/jats:styled-content>49d\u2010positive CLL<\/jats:styled-content> patients experience a disease course dominated by lymphadenopathy. These findings could have implications for therapy selection and disease monitoring.<\/jats:p>","DOI":"10.1111\/bjh.14647","type":"journal-article","created":{"date-parts":[[2017,4,7]],"date-time":"2017-04-07T06:08:46Z","timestamp":1491545326000},"page":"99-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["CD<\/scp>49d associates with nodal presentation and subsequent development of lymphadenopathy in patients with chronic lymphocytic leukaemia"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-1459","authenticated-orcid":false,"given":"Paolo","family":"Strati","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer A.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN 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