{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:20:32Z","timestamp":1775168432987,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T00:00:00Z","timestamp":1493078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"Summary<\/jats:title>The efficacy of high\u2010dose cytarabine (HDCA<\/jats:styled-content>) plus cyclophosphamide\/total\u2010body irradiation (CY<\/jats:styled-content>\/TBI<\/jats:styled-content>) has been proved in cord blood transplantation (CBT<\/jats:styled-content>) for acute lymphoblastic leukaemia (ALL<\/jats:styled-content>), but not in bone marrow or peripheral blood stem cell transplantation (BMT<\/jats:styled-content>\/PBSCT<\/jats:styled-content>). In this cohort study, we compared the prognosis of CY<\/jats:styled-content>\/TBI<\/jats:styled-content> (N\u00a0<\/jats:italic>=\u00a0<\/jats:italic>1244) and HDCA<\/jats:styled-content>\/CY<\/jats:styled-content>\/TBI<\/jats:styled-content> (N\u00a0<\/jats:italic>=\u00a0<\/jats:italic>316) regimens in BMT<\/jats:styled-content>\/PBSCT<\/jats:styled-content> for ALL<\/jats:styled-content>. The addition of HDCA<\/jats:styled-content> decreased post\u2010transplant relapse, while significantly increasing non\u2010relapse mortality (risk ratio, 1\u00b733), and overall survival was not improved. The positive effects of HDCA<\/jats:styled-content> reported in CBT<\/jats:styled-content> cannot be extrapolated to BMT<\/jats:styled-content>\/PBSCT<\/jats:styled-content>, and HDCA<\/jats:styled-content> may not be recommended in these procedures.<\/jats:p>","DOI":"10.1111\/bjh.14652","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T08:58:57Z","timestamp":1493110737000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Increased non\u2010relapse mortality due to high\u2010dose cytarabine plus CY<\/scp>\/TBI<\/scp> in BMT<\/scp>\/PBSCT<\/scp> for acute lymphoblastic leukaemia in adults"],"prefix":"10.1111","volume":"178","author":[{"given":"Yasuyuki","family":"Arai","sequence":"first","affiliation":[{"name":"Department of Haematology and Oncology Graduate School of Medicine Kyoto University Kyoto Japan"},{"name":"Laboratory of Host Defences National Institute 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