{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T04:17:46Z","timestamp":1790396266787,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T00:00:00Z","timestamp":1492387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006259","name":"Teva Pharmaceutical Industries","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006259","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite the long history of bendamustine as treatment for indolent non\u2010Hodgkin lymphoma, long\u2010term efficacy and toxicity data are minimal. We reviewed long\u2010term data from three clinical trials to characterize the toxicity and efficacy of patients receiving bendamustine. Data were available for 149 subjects at 21 sites. The median age was 60\u00a0years at the start of bendamustine (range 39\u201384), and patients had received a median of 3 prior therapies. The histologies included grades 1\u20132 follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>;<jats:italic> n<\/jats:italic>\u00a0=\u00a073), grade 3 <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> (<jats:italic>n<\/jats:italic>\u00a0=\u00a023), small lymphocytic lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a020), marginal zone lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a015), mantle cell lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a09), transformed lymphomas (<jats:italic>n<\/jats:italic>\u00a0=\u00a05), lymphoplasmacytic lymphoma (<jats:italic>n<\/jats:italic>\u00a0=\u00a02) and not reported (<jats:italic>n<\/jats:italic>\u00a0=\u00a02). The median event\u2010free survival was 14\u00b71\u00a0months. Nine of 12 attempted stem cell collections were successful. With a median follow\u2010up of 8\u00b79\u00a0years, 23 patients developed 25 cancers, including 8 patients with myelodysplastic syndrome\/acute myeloid leukaemia. These data provide important information regarding the long\u2010term toxicity of bendamustine in previously treated patients. A small but meaningful number of patients achieved durable remissions following bendamustine. These rigorously collected, patient\u2010level, long\u2010term follow\u2010up data provide reassurance that bendamustine or bendamustine plus rituximab is associated with efficacy and safety for patients with relapsed or refractory indolent non\u2010Hodgkin lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.14667","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T10:02:44Z","timestamp":1492423364000},"page":"250-256","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Long\u2010term outcomes, secondary malignancies and stem cell collection following bendamustine in patients with previously treated non\u2010Hodgkin lymphoma"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-1551","authenticated-orcid":false,"given":"Peter","family":"Martin","sequence":"first","affiliation":[{"name":"Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce D.","family":"Cheson","sequence":"additional","affiliation":[{"name":"Georgetown University Hospital Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine S.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Dalhousie University Halifax NS Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Williams","sequence":"additional","affiliation":[{"name":"University of Virginia Health System Charlottesville VA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh A.","family":"Rajguru","sequence":"additional","affiliation":[{"name":"University of Wisconsin Hospital Madison WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan W.","family":"Friedberg","sequence":"additional","affiliation":[{"name":"University of Rochester Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H.","family":"van der Jagt","sequence":"additional","affiliation":[{"name":"Ottawa Hospital Ottawa ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann S.","family":"LaCasce","sequence":"additional","affiliation":[{"name":"Dana\u2010Farber Cancer Institute Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Joyce","sequence":"additional","affiliation":[{"name":"Beth Israel Deconess Medical Center Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen N.","family":"Ganjoo","sequence":"additional","affiliation":[{"name":"Stanford University San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy L.","family":"Bartlett","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Lemieux","sequence":"additional","affiliation":[{"name":"Centre Hospitalier de l'Universite de Montreal Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"VanderWalde","sequence":"additional","affiliation":[{"name":"West Cancer Center Memphis TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordan","family":"Herst","sequence":"additional","affiliation":[{"name":"Health Sciences North Sudbury ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Szer","sequence":"additional","affiliation":[{"name":"Royal Melbourne Hospital Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael H.","family":"Bar","sequence":"additional","affiliation":[{"name":"Bennet Cancer Center Stamford CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cabanillas","sequence":"additional","affiliation":[{"name":"Auxillio Cancer Center San Juan Puerto Rico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony J.","family":"Dodds","sequence":"additional","affiliation":[{"name":"St. Vincent's Hospital Sydney NSW Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul G.","family":"Montgomery","sequence":"additional","affiliation":[{"name":"St. Luke's Mountain States Tumor Institute Boise ID USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryn","family":"Pressnail","sequence":"additional","affiliation":[{"name":"Royal Victoria Hospital Barrie ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tricia","family":"Ellis","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1428-8765","authenticated-orcid":false,"given":"Mitchell R.","family":"Smith","sequence":"additional","affiliation":[{"name":"Cleveland Clinic Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Weill Cornell Medicine New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040342"},{"key":"e_1_2_7_3_1","first-page":"2679","article-title":"Peripheral blood stem cell mobilization after bendamustine containing chemotherapy in indolent lymphomas is possible. 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