{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:25:35Z","timestamp":1747290335148,"version":"3.37.3"},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T00:00:00Z","timestamp":1495670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"PrioMedChild","award":["40-41800-98-027"],"award-info":[{"award-number":["40-41800-98-027"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A better understanding of the reconstitution of the B\u2010cell compartment during and after treatment in B\u2010cell precursor acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) will help to assess the immunological status and needs of post\u2010treatment <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> patients. Using 8\u2010colour flow cytometry and proliferation\u2010assays, we studied the composition and proliferation of both the B\u2010cell precursor (<jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>) population in the bone marrow (<jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content>) and mature B\u2010cell population in peripheral blood (<jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>) during and after <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> therapy. We found a normal <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> differentiation pattern and a delayed formation of classical <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>38<jats:sup>dim<\/jats:sup>\u2010naive mature B\u2010cells, natural effector B\u2010cells and memory B\u2010cells in patients after chemotherapy. This B\u2010cell differentiation\/maturation pattern was strikingly similar to that during initial B\u2010cell development in healthy infants. Tissue\u2010resident plasma cells appeared to be partly protected from chemotherapy. Also, we found that the fast recovery of naive mature B\u2010cell numbers after chemotherapy was the result of increased <jats:italic>de novo <\/jats:italic><jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content> generation, rather than enhanced B\u2010cell proliferation in <jats:styled-content style=\"fixed-case\">BM<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PB<\/jats:styled-content>. These results indicate that post\u2010treatment <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> patients will eventually re\u2010establish a B\u2010cell compartment with a composition and B\u2010cell receptor repertoire similar to that in healthy children. Additionally, the formation of a new memory B\u2010cell compartment suggests that revaccination might be beneficial after <jats:styled-content style=\"fixed-case\">BCP<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> therapy.<\/jats:p>","DOI":"10.1111\/bjh.14685","type":"journal-article","created":{"date-parts":[[2017,5,25]],"date-time":"2017-05-25T17:17:49Z","timestamp":1495732669000},"page":"267-278","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Understanding the reconstitution of the B\u2010cell compartment in bone marrow and blood after treatment for B\u2010cell precursor acute lymphoblastic leukaemia"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-7734","authenticated-orcid":false,"given":"Prisca M. 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