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Mocetinostat, an isotype\u2010selective <jats:styled-content style=\"fixed-case\">HDAC<\/jats:styled-content> inhibitor, induces accumulation of acetylated histones, cell cycle arrest and apoptosis in several cancers. This phase 2 study evaluated mocetinostat in patients with relapsed\/refractory (R\/R) <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. Seventy\u2010two patients received mocetinostat (starting doses: 70\u2013110\u00a0mg <jats:styled-content style=\"fixed-case\">TIW<\/jats:styled-content>, 4\u2010week cycles). The best overall response rate (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) was 18\u00b79% (7\u00b72, 32\u00b72) for the <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a041), and 11\u00b75% (1\u00b77, 20\u00b77) for the <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> cohort (<jats:italic>n<\/jats:italic>\u00a0=\u00a031). Responses were durable (\u226590\u00a0days in 7 of 10 responses). Overall, 54\u00b71% and 73\u00b71% of patients derived clinical benefit (response or stable disease) from mocetinostat in the <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> cohorts, respectively. Progression\u2010free survival ranged from 1\u00b78 to 22\u00b78\u00a0months and 11\u00b78 to 26\u00b73\u00a0months in responders with <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, respectively. The most frequent treatment\u2010related adverse events were fatigue (75\u00b70%), nausea (69\u00b74%) and diarrhoea (61\u00b71%). Although mocetinostat had limited single\u2010agent activity in R\/R <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>, patients with clinical benefit had long\u2010term disease control. The safety profile was acceptable. This drug class warrants further investigation, including identifying patients more likely to respond to this agent, or in combination with other agents.<\/jats:p>","DOI":"10.1111\/bjh.14698","type":"journal-article","created":{"date-parts":[[2017,4,25]],"date-time":"2017-04-25T10:15:02Z","timestamp":1493115302000},"page":"434-441","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["A phase 2 study of mocetinostat, a histone deacetylase inhibitor, in relapsed or refractory lymphoma"],"prefix":"10.1111","volume":"178","author":[{"given":"Connie L.","family":"Batlevi","sequence":"first","affiliation":[{"name":"Lymphoma Service Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Crump","sequence":"additional","affiliation":[{"name":"Princess Margaret Cancer Center Toronto ON Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charalambos","family":"Andreadis","sequence":"additional","affiliation":[{"name":"UCSF Helen Diller Family Comprehensive Cancer Center San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rizzieri","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarit E.","family":"Assouline","sequence":"additional","affiliation":[{"name":"McGill University Montreal QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Fox","sequence":"additional","affiliation":[{"name":"Charles LeMoyne Hospital Greenfield Park QC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard H. 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