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We assessed 66 cases of primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and 309 control <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, not otherwise specified. Hepatitis C virus antibody prevalence, B symptoms, poor performance status and <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 positivity differed significantly between the primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and control <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> groups. Primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> cases were classified histopathologically into two groups [white pulp pattern (<jats:italic>n<\/jats:italic>\u00a0=\u00a046), red pulp pattern (<jats:italic>n<\/jats:italic>\u00a0=\u00a020)]. Survival analysis showed no difference in overall survival between the primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> and the control group, but the former had a more favourable progression\u2010free survival. In the examination of primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, the white pulp pattern was statistically associated with a lower performance status (2\u20134), and a lower <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 positivity than the red pulp pattern. In the survival analysis, the red pulp pattern demonstrated poorer overall survival. Multivariate analysis of overall survival in primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> cases identified <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>5 positivity as an indicator of poor prognosis. Classifying primary splenic <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> into white and red pulp patterns was useful in terms of clinicopathological features and overall survival.<\/jats:p>","DOI":"10.1111\/bjh.14736","type":"journal-article","created":{"date-parts":[[2017,5,11]],"date-time":"2017-05-11T15:20:33Z","timestamp":1494516033000},"page":"719-727","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinicopathological analysis of primary splenic diffuse large B\u2010cell lymphoma"],"prefix":"10.1111","volume":"178","author":[{"given":"Joji","family":"Shimono","sequence":"first","affiliation":[{"name":"Department of Pathology Kurume University School of Medicine Kurume Japan"},{"name":"Department of Haematology Hokkaido University Graduate School of Medicine Sapporo 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