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This review summarizes the basic concepts and cornerstones of the classification of aggressive B\u2010cell lymphomas and details the major changes. Of importance, there is a new concept of High\u2010grade B\u2010cell lymphomas (<jats:styled-content style=\"fixed-case\">HGBL<\/jats:styled-content>), partly replacing the provisional entity of B\u2010cell lymphoma, unclassifiable, with features intermediate between diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>) and Burkitt lymphoma, the so\u2010called grey zone lymphomas. They either harbour <jats:italic><jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content><\/jats:italic> translocations together with a <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>2<\/jats:italic> and\/or a <jats:italic><jats:styled-content style=\"fixed-case\">BCL<\/jats:styled-content>6<\/jats:italic> rearrangement (<jats:styled-content style=\"fixed-case\">HGBL<\/jats:styled-content>\u2010Double Hit) or <jats:styled-content style=\"fixed-case\">HGBL<\/jats:styled-content>, not otherwise specified (<jats:styled-content style=\"fixed-case\">NOS<\/jats:styled-content>), lacking a double or triple hit constellation. In addition, the requirement for providing the cell\u2010of\u2010origin classification in the diagnostic work\u2010up of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>s, the role of <jats:styled-content style=\"fixed-case\">MYC<\/jats:styled-content> alterations in <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> subtypes, and newer findings in the specific variants\/subtypes are highlighted.<\/jats:p>","DOI":"10.1111\/bjh.14744","type":"journal-article","created":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T08:10:35Z","timestamp":1501143035000},"page":"871-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Aggressive B\u2010cell lymphomas in the update of the 4th edition of the World Health Organization classification of haematopoietic and lymphatic tissues: refinements of the classification, new entities and genetic 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