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Over\u2010anticoagulated patients present with a wide range of International Normalised Ratio (<jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content>) values and response to fixed doses of vitamin K varies. Consequently a significant proportion of patients remain outside their target <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> after vitamin K administration, making them prone to either haemorrhage or thromboembolism. We compared the performance of a novel tailored vitamin K dosing regimen to that of a fixed\u2010dose regimen with the primary measure being the proportion of over\u2010anticoagulated patients returning to their target <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> within 24\u00a0h. One hundred and eighty\u2010one patients with an index INR\u00a0&gt;\u00a06\u00b70 (asymptomatic or with minor bleeding) were randomly allocated to receive oral administration of either a tailored dose (based upon index <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> and body surface area) or a fixed\u2010dose (1 or 2\u00a0mg) of vitamin K. A greater proportion of patients treated with the tailored dose returned to within target <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> range compared to the fixed\u2010dose regimen (68\u00b79% vs. 52\u00b78%; <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7026), whilst a smaller proportion of patients remained above target <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> range (12\u00b72% vs. 34\u00b70%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Individualised vitamin K dosing is more accurate than fixed\u2010dose regimen in lowering <jats:styled-content style=\"fixed-case\">INR<\/jats:styled-content> to within target range in excessively anticoagulated patients.<\/jats:p>","DOI":"10.1111\/bjh.14777","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T19:32:29Z","timestamp":1501788749000},"page":"800-809","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of the efficacy of a novel tailored vitamin K dosing regimen in lowering the International Normalised Ratio in over\u2010anticoagulated patients: a randomised clinical trial"],"prefix":"10.1111","volume":"178","author":[{"given":"Emmanouela","family":"Kampouraki","sequence":"first","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Avery","sequence":"additional","affiliation":[{"name":"School of Mathematics &amp; Statistics, Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilary","family":"Wynne","sequence":"additional","affiliation":[{"name":"Older People's Medicine Freeman Hospital Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tina","family":"Biss","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Victoria Infirmary Newcastle upon Tyne United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Hanley","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Victoria Infirmary Newcastle upon Tyne United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Talks","sequence":"additional","affiliation":[{"name":"Department of Haematology Royal Victoria Infirmary Newcastle upon Tyne United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-4017","authenticated-orcid":false,"given":"Farhad","family":"Kamali","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine, Newcastle University Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,8,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.05.022"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-372722"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2010.03784.x"},{"key":"e_1_2_9_5_1","unstructured":"Chibisov I.(2007)Strategies for Reversal of Anticoagulants Part I: Warfarin Unfractionated Heparin and Low Molecular Weight Heparins. 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