{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T11:09:43Z","timestamp":1788174583316,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,6,4]],"date-time":"2017-06-04T00:00:00Z","timestamp":1496534400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007322","name":"Fox Chase Cancer Center","doi-asserted-by":"publisher","award":["P30 CA015083"],"award-info":[{"award-number":["P30 CA015083"]}],"id":[{"id":"10.13039\/100007322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    The ultimate cause of death for most patients with newly diagnosed chronic lymphocytic leukaemia (\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    ) and its relationship to co\u2010morbid health conditions is poorly defined. We conducted a prospective cohort study that systematically followed 1143 patients diagnosed with\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    between June 2002 and November 2014. Comorbid health conditions at the time of\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    diagnosis and their relationship to survival and cause of death were evaluated. Collectively, 1061 (93%) patients had at least one co\u2010morbid health condition at the time of\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    diagnosis (median number 3). Despite this, 89% of patients had a low\u2010intermediate Charlson Comorbidity Index score (\n                    <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\n                    ) at diagnosis. After a median follow\u2010up of 6\u00a0years, 225 patients have died. Death was due to\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    progression in 85 (46%) patients, infection in 14 (8%) patients, other cancer in 35 (19%) patients and comorbid health conditions in 50 (27%) patients. Higher\n                    <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\n                    score and a greater number of major comorbid health conditions at the time of\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    diagnosis was associated with shorter non\u2010\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    specific survival, but not with shorter\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    \u2010specific survival on multivariate analysis. In conclusion,\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    \u2010related complications (infections and second cancers) are the overwhelming cause of death in patients with\n                    <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\n                    , regardless of\n                    <jats:styled-content style=\"fixed-case\">CCI<\/jats:styled-content>\n                    score and number of comorbid health conditions at diagnosis.\n                  <\/jats:p>","DOI":"10.1111\/bjh.14785","type":"journal-article","created":{"date-parts":[[2017,6,5]],"date-time":"2017-06-05T00:24:44Z","timestamp":1496622284000},"page":"394-402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["Relationship between co\u2010morbidities at diagnosis, survival and ultimate cause of death in patients with chronic lymphocytic leukaemia (\n                    <scp>CLL<\/scp>\n                    ): a prospective cohort study"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7445-1459","authenticated-orcid":false,"given":"Paolo","family":"Strati","sequence":"first","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer A.","family":"Parikh","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kari G.","family":"Chaffee","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil E.","family":"Kay","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy G.","family":"Call","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara J.","family":"Achenbach","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tait D.","family":"Shanafelt","sequence":"additional","affiliation":[{"name":"Mayo Clinic College of Medicine Rochester MN 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