{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T01:24:25Z","timestamp":1789176265464,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T00:00:00Z","timestamp":1496275200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Eltrombopag is a second\u2010line treatment in primary immune thrombocytopenia (<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content>). However, its role in secondary <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> is unknown. We evaluated the efficacy and safety of eltrombopag in secondary <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> in daily clinical practice. Eighty\u2010seven secondary <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> patients (46 with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> secondary to autoimmune syndromes, 23 with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> secondary to a neoplastic disease subtype: lymphoproliferative disorders [<jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>s] and 18 with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> secondary to viral infections) who had been treated with eltrombopag were retrospectively evaluated. Forty\u2010four patients (38%) had a platelet response, including 40 (35%) with complete responses. Median time to platelet response was 15\u00a0days (95% confidence interval, 7\u201328\u00a0days), and was longer in the <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> group. Platelet response rate was significantly lower in the <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> than in other groups. However, having achieved response, there were no significant differences between the durable response of the groups. Forty\u2010three patients (49\u00b74%) experienced adverse events (mainly grade 1\u20132), the commonest being hepatobiliary laboratory abnormalities. There were 10 deaths in this case series, all of which were related to pre\u2010existing medical conditions. In routine clinical practice, eltrombopag is effective and well\u2010tolerated in unselected patients with <jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> secondary to both immune and infectious disorders. However, the response rate in <jats:styled-content style=\"fixed-case\">LPD<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ITP<\/jats:styled-content> is low.<\/jats:p>","DOI":"10.1111\/bjh.14788","type":"journal-article","created":{"date-parts":[[2017,6,2]],"date-time":"2017-06-02T04:02:47Z","timestamp":1496376167000},"page":"959-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Use of eltrombopag for secondary immune thrombocytopenia in clinical practice"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-2554","authenticated-orcid":false,"given":"Tom\u00e1s J.","family":"Gonz\u00e1lez\u2010L\u00f3pez","sequence":"first","affiliation":[{"name":"Department of Haematology Hospital Universitario de Burgos Burgos Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda T.","family":"Alvarez\u2010Rom\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Universitario La Paz Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pascual","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Universitario Gregorio Mara\u00f1\u00f3n Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blanca","family":"S\u00e1nchez\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital del Mar Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Fern\u00e1ndez\u2010Fuentes","sequence":"additional","affiliation":[{"name":"Department of Haematology Hospital Universitario Insular de Gran Canaria Las Palmas de Gran Canaria 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