{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:02:42Z","timestamp":1793905362679,"version":"4.8.0"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T00:00:00Z","timestamp":1498176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sanofi K.K."}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The clinical significance of paroxysmal nocturnal haemoglobinuria (<jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content>) in children with aplastic anaemia (<jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content>) remains unclear. We retrospectively studied 57 children with <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> between 1992 and 2010. During the follow\u2010up, five patients developed clinical <jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content>, in whom somatic <jats:italic><jats:styled-content style=\"fixed-case\">PIGA<\/jats:styled-content><\/jats:italic> mutations were detected by targeted sequencing. The 10\u2010year probability of clinical <jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content> development was 10\u00b72% (95% confidence interval, 3\u00b76\u201320\u00b77%). Furthermore, the detection of minor <jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content> clones by flow cytometry at <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> diagnosis was a risk factor for the subsequent development of clinical <jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content>. These patients with <jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content> clones at <jats:styled-content style=\"fixed-case\">AA<\/jats:styled-content> diagnosis should undergo periodic monitoring for potential clinical <jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content> development.<\/jats:p>","DOI":"10.1111\/bjh.14790","type":"journal-article","created":{"date-parts":[[2017,6,23]],"date-time":"2017-06-23T07:56:44Z","timestamp":1498204604000},"page":"954-958","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Development of clinical paroxysmal nocturnal haemoglobinuria in children with aplastic anaemia"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6518-4726","authenticated-orcid":false,"given":"Atsushi","family":"Narita","sequence":"first","affiliation":[{"name":"Department of Paediatrics Nagoya University Graduate School of Medicine Nagoya 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