{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T05:02:09Z","timestamp":1789016529033,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,8]]},"abstract":"Summary<\/jats:title>\n \n The best approach for allogeneic haematopoietic stem cell transplantations (allo\n HCT<\/jats:styled-content>\n ) in patients with chronic lymphocytic leukaemia (\n CLL<\/jats:styled-content>\n ) is unknown. We therefore analysed the impact of procedure\u2010 and centre\u2010related factors on 5\u2010year event\u2010free survival (\n EFS<\/jats:styled-content>\n ) in a large retrospective study. Data of 684\n CLL<\/jats:styled-content>\n patients who received a first allo\n HCT<\/jats:styled-content>\n between 2000 and 2011 were analysed by multivariable Cox proportional hazards models with a frailty component to investigate unexplained centre heterogeneity. Five\u2010year\n EFS<\/jats:styled-content>\n of the whole cohort was 37% (95% confidence interval [\n CI<\/jats:styled-content>\n ], 34\u201342%). Larger numbers of\n CLL<\/jats:styled-content>\n allo\n HCT<\/jats:styled-content>\n s (hazard ratio [\n HR<\/jats:styled-content>\n ] 0\u00b796,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7002), certification of quality management (\n HR<\/jats:styled-content>\n 0\u00b77,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b7045) and a higher gross national income per capita (\n HR<\/jats:styled-content>\n 0\u00b74,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b704) improved\n EFS<\/jats:styled-content>\n .\n In vivo<\/jats:italic>\n T\u2010cell depletion (\n TCD<\/jats:styled-content>\n ) with alemtuzumab compared to no\n TCD<\/jats:styled-content>\n (\n HR<\/jats:styled-content>\n 1\u00b75,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b703), and a female donor compared to a male donor for a male patient (\n HR<\/jats:styled-content>\n 1\u00b74,\n P<\/jats:italic>\n \u00a0=\u00a00\u00b702) had a negative impact on\n EFS<\/jats:styled-content>\n , but not non\u2010myeloablative versus more intensive conditioning. After correcting for patient\u2010, procedure\u2010 and centre\u2010characteristics, significant variation in centre outcomes persisted. In conclusion, further research on the impact of centre and procedural characteristics is warranted. Non\u2010myeloablative conditioning appears to be the preferable approach for patients with\n CLL<\/jats:styled-content>\n .\n <\/jats:p>","DOI":"10.1111\/bjh.14791","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T04:18:03Z","timestamp":1496809083000},"page":"521-533","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Centre characteristics and procedure\u2010related factors have an impact on outcomes of allogeneic transplantation for patients with\n CLL<\/scp>\n : a retrospective analysis from the European Society for Blood and Marrow Transplantation (\n EBMT<\/scp>\n )"],"prefix":"10.1111","volume":"178","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2780-2981","authenticated-orcid":false,"given":"Johannes","family":"Schetelig","sequence":"first","affiliation":[{"name":"Medical Department I University Hospital of the Technical University Dresden Dresden Germany"},{"name":"DKMS Clinical Trials Unit Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesbeth C.","family":"de Wreede","sequence":"additional","affiliation":[{"name":"DKMS Clinical Trials Unit Dresden Germany"},{"name":"Department of Medical Statistics & Bioinformatics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels S.","family":"Andersen","sequence":"additional","affiliation":[{"name":"BMT Unit Department of Haematology Rigshospitalet Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Moreno","sequence":"additional","affiliation":[{"name":"Hematologia Hospital de la Santa Creu i Sant Pau Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"van Gelder","sequence":"additional","affiliation":[{"name":"University Medical Centre Maastricht Maastricht The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Vitek","sequence":"additional","affiliation":[{"name":"Department of Haematology Institute of Haematology and Blood Transfusion Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal","family":"Karas","sequence":"additional","affiliation":[{"name":"Department of Haematology\/Oncology Charles University Hospital Pilsen Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricette","family":"Michallet","sequence":"additional","affiliation":[{"name":"Centre Hospitalier Lyon\u2010Sud \u2013 H\u00e9matologie Lyon France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Machaczka","sequence":"additional","affiliation":[{"name":"Haematology Centre Karolinska and Department of Medicine at Huddinge Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gramatzki","sequence":"additional","affiliation":[{"name":"Division of Stem Cell Transplantation and Immunotherapy University Hospital Schleswig\u2010Holstein Kiel Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"Beelen","sequence":"additional","affiliation":[{"name":"Department of Bone Marrow Transplantation University Hospital Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Finke","sequence":"additional","affiliation":[{"name":"Department of Medicine \u2010 Haematology, Oncology University of Freiburg Freiburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Delgado","sequence":"additional","affiliation":[{"name":"Institute of Haematology & Oncology Department of Haematology Hospital Clinic Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liisa","family":"Volin","sequence":"additional","affiliation":[{"name":"Stem Cell Transplantation Unit Helsinki University Hospital Comprehensive Cancer Centre Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob","family":"Passweg","sequence":"additional","affiliation":[{"name":"Department for Haematology University Hospital Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Dreger","sequence":"additional","affiliation":[{"name":"Medizinische Klinik u. Poliklinik V University of Heidelberg Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaas","family":"Schaap","sequence":"additional","affiliation":[{"name":"Radboud University Medical Centre Nijmegen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Wagner","sequence":"additional","affiliation":[{"name":"University Medical Centre Mainz Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Henseler","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics & Bioinformatics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"van Biezen","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics & Bioinformatics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bornh\u00e4user","sequence":"additional","affiliation":[{"name":"Medical Department I University Hospital of the Technical University Dresden Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Iacobelli","sequence":"additional","affiliation":[{"name":"Department of Biology University of Tor Vergata Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hein","family":"Putter","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics & Bioinformatics Leiden University Medical Centre Leiden The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan O.","family":"Sch\u00f6nland","sequence":"additional","affiliation":[{"name":"Department of Haematology Institute of Haematology and Blood Transfusion Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaus","family":"Kr\u00f6ger","sequence":"additional","affiliation":[{"name":"Bone Marrow Transplantation Centre University Hospital Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the CLL subcommittee, Chronic Malignancies Working Party","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19990630)18:12<1489::AID-SIM140>3.0.CO;2-#"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2009.07.004"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1201\/b11826"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1400376"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-14-2809"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-08-3372"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V126.23.490.490"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403745"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404441"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-07-586826"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1315226"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1599"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.30.4121"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2013.096461"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2015.11.021"},{"key":"e_1_2_9_18_1","unstructured":"Gray B.(2014)Gray B: Package \u2018cmprsk: Subdistribution Analysis of Competing Risks\u2019. 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