{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T12:02:36Z","timestamp":1769601756895,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T00:00:00Z","timestamp":1499212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Clinical trials enrolling follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) patients typically require bone marrow biopsies (<jats:styled-content style=\"fixed-case\">BMB<\/jats:styled-content>s) at baseline and at a subsequent point if complete response is achieved. These procedures are painful, take time and add cost. We hypothesized that <jats:styled-content style=\"fixed-case\">BMB<\/jats:styled-content>s do not provide information significant for response assessment in most follicular lymphoma patients on clinical trials. We identified 99 patients treated on clinical trials for follicular lymphoma between 2000 and 2016. <jats:styled-content style=\"fixed-case\">BMB<\/jats:styled-content>s resulted in a possible response assessment change in 1\u00b70% of patients (95% confidence interval: 0\u00b70\u20135\u00b75%). We conclude that mandatory <jats:styled-content style=\"fixed-case\">BMB<\/jats:styled-content>s at baseline and for response assessment are unnecessary in clinical trials for follicular lymphoma.<\/jats:p>","DOI":"10.1111\/bjh.14839","type":"journal-article","created":{"date-parts":[[2017,7,5]],"date-time":"2017-07-05T10:45:06Z","timestamp":1499251506000},"page":"242-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Bone marrow biopsies do not impact response assessment for follicular lymphoma patients treated on clinical trials"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1064-7727","authenticated-orcid":false,"given":"Sarah C.","family":"Rutherford","sequence":"first","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Meyer Cancer Center Weill Cornell Medical College and New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valery","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Meyer Cancer Center Weill Cornell Medical College and New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Ghione","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Meyer Cancer Center Weill Cornell Medical College and New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Healthcare Policy and Research Division of Biostatistics and Epidemiology Weill Cornell Medical College New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7813-1551","authenticated-orcid":false,"given":"Peter","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Meyer Cancer Center Weill Cornell Medical College and New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Leonard","sequence":"additional","affiliation":[{"name":"Department of Medicine Division of Hematology and Oncology Meyer Cancer Center Weill Cornell Medical College and New York\u2010Presbyterian Hospital New York NY USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,5]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.112.114710"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.09.2403"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.54.8800"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-12-473389"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000002910"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14071"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14839","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T03:23:35Z","timestamp":1696044215000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14839"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,5]]},"references-count":7,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1111\/bjh.14839"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14839","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,5]]},"assertion":[{"value":"2017-04-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-05-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}