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The scars of this war are carried in the human genome in the form of polymorphisms that confer innate resistance to malaria. Clinical, epidemiological and genome\u2010wide association studies have identified multiple polymorphisms in red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) proteins that attenuate malaria pathogenesis. These include well\u2010known polymorphisms in haemoglobin, intracellular enzymes,<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>channels,<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>surface markers, and proteins impacting the<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>cytoskeleton and<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>morphology. 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