{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T22:43:06Z","timestamp":1767998586667,"version":"3.49.0"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T00:00:00Z","timestamp":1506643200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A 14\u2010year\u2010old boy with relapsed T cell acute lymphoblastic leukaemia received reinduction chemotherapy that included nelarabine, a purine nucleoside analogue known to cause dose\u2010dependent neurotoxicity. Although he achieved aminimal residual disease negative remission after two cycles of chemotherapy he also developed severe, progressive peripheral and central neurotoxicities. Loss of grey\u2010white differentiation was seen on a T2\u2010weighted magnetic resonance imaging brain scan. This unusual clinical picture and previously unreported radiological findings are thought to be due to nelarabine toxicity. He was bridged with 6\u2010mercaptopurine while transplant was deferred pending sustainable neurological improvement. This case posed clinical and ethical dilemmas while demonstrating previously unreported radiological features.<\/jats:p>","DOI":"10.1111\/bjh.14921","type":"journal-article","created":{"date-parts":[[2017,9,29]],"date-time":"2017-09-29T16:53:24Z","timestamp":1506704004000},"page":"294-297","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Nelarabine\u2010induced peripheral and central neurotoxicity: can sequential <scp>MRI<\/scp> brain imaging help to define its natural history?"],"prefix":"10.1111","volume":"179","author":[{"given":"Karl","family":"Ewins","sequence":"first","affiliation":[{"name":"Department of Paediatric Haematology Our Lady's Children's Hospital Crumlin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Malone","sequence":"additional","affiliation":[{"name":"Department of Paediatric Haematology Our Lady's Children's Hospital Crumlin Dublin Ireland"},{"name":"University College Dublin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ethna","family":"Phelan","sequence":"additional","affiliation":[{"name":"Department of Radiology Our Lady's Children's Hospital Crumlin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Webb","sequence":"additional","affiliation":[{"name":"Department of Neurology Our Lady's Children's Hospital Crumlin Dublin Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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