{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:02:26Z","timestamp":1784257346587,"version":"3.55.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T00:00:00Z","timestamp":1507766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS070711"],"award-info":[{"award-number":["NS070711"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS040538"],"award-info":[{"award-number":["NS040538"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL128371"],"award-info":[{"award-number":["HL128371"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NS087716"],"award-info":[{"award-number":["NS087716"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["GM080202"],"award-info":[{"award-number":["GM080202"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Sickle cell trait (<jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content>) has classically been categorized as a benign condition except in rare cases or upon exposure to severe physical conditions. However, several lines of evidence indicate that individuals with <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> are not always asymptomatic, and additional physiological changes and risks may remain unexplored. Here, we utilized mice harbouring one copy of normal human \u03b2 globin and one copy of sickle human \u03b2 globin as a model of <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> to assess haematological, histopathological and somatosensory outcomes. We observed that <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> mice displayed renal and hepatic vascular congestion after exposure to hypoxia. Further, we observed that <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> mice displayed increased cold aversion as well as mechanical and heat sensitivity, though to a lesser degree than homozygous sickle cell disease mice. Notably, mechanical hypersensitivity increased following hypoxia and reoxygenation. Overall our findings suggest that <jats:styled-content style=\"fixed-case\">SCT<\/jats:styled-content> is not entirely benign, and further assessment of pain and cutaneous sensitization is warranted both in animal models and in clinical populations.<\/jats:p>","DOI":"10.1111\/bjh.14948","type":"journal-article","created":{"date-parts":[[2017,10,13]],"date-time":"2017-10-13T04:52:41Z","timestamp":1507870361000},"page":"657-666","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Characterization of a mouse model of sickle cell trait: parallels to human trait and a novel finding of cutaneous sensitization"],"prefix":"10.1111","volume":"179","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4419-4834","authenticated-orcid":false,"given":"Katherine J.","family":"Zappia","sequence":"first","affiliation":[{"name":"Department of Cell Biology, Neurobiology &amp; Anatomy Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihe","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Biology UNC Fayetteville State University Fayetteville NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dawn","family":"Retherford","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Children's Research Institute Medical College of Wisconsin Milwaukee WI USA"},{"name":"Blood Research Institute Blood Center of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy J.","family":"Wandersee","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Children's Research Institute Medical College of Wisconsin Milwaukee WI USA"},{"name":"Blood Research Institute Blood Center of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4966-6594","authenticated-orcid":false,"given":"Cheryl L.","family":"Stucky","sequence":"additional","affiliation":[{"name":"Department of Cell Biology, Neurobiology &amp; Anatomy Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1252-7497","authenticated-orcid":false,"given":"Cheryl A.","family":"Hillery","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Children's Research Institute Medical College of Wisconsin Milwaukee WI USA"},{"name":"Blood Research Institute Blood Center of Wisconsin Milwaukee WI USA"},{"name":"Division of Pediatric Hematology\/Oncology University of Pittsburgh School of Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,10,12]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"908","article-title":"Sickle cell trait and the risk of venous thromboembolism among blacks","volume":"110","author":"Austin H.","year":"2007","journal-title":"Cell"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23341"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2011.08977.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/j.pain.0000000000000104"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0270(94)90144-9"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2016.10.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pa.20.040180.002301"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.12787"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60692-4"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(88)90026-7"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.008037"},{"key":"e_1_2_8_13_1","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1182\/blood.V87.11.4879.bloodjournal87114879","article-title":"Increased adhesion of erythrocytes to components of the extracellular matrix: isolation and characterization of a red blood cell lipid that binds thrombospondin and laminin","volume":"87","author":"Hillery C.A.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-12-327429"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000214"},{"key":"e_1_2_8_16_1","first-page":"4862","article-title":"Glycoprotein IV\u2010Independent Adhesion","volume":"87","author":"Joneckis C.C.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2011.09.014"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198709243171301"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-06-2373"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13363"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2010-01-260372"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160608"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-727719"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2839"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2015.1.160"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1516257"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1526-4637.2009.00601.x"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2001.0469"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.278.5339.876"},{"key":"e_1_2_8_30_1","first-page":"1562","article-title":"Sickle cell trait: what are the costs and benefits of screening?","volume":"56","author":"Shephard R.J.","year":"2016","journal-title":"The Journal of sports medicine and physical fitness"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-148-2-200801150-00004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1182\/blood.V80.10.2634.2634","article-title":"Thrombospondin mediates adherence of CD36\u00a0+\u00a0 sickle reticulocytes to endothelial cells","volume":"80","author":"Sugihara K.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.07.034"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2008.12.020"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.10.004"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-02-004812"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2014.05.030"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M038281"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5LC00543D"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.14948","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.14948","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T08:20:47Z","timestamp":1695975647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.14948"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,12]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["10.1111\/bjh.14948"],"URL":"https:\/\/doi.org\/10.1111\/bjh.14948","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10,12]]},"assertion":[{"value":"2017-05-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}