{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T20:05:17Z","timestamp":1762459517841,"version":"3.37.3"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,18]],"date-time":"2017-10-18T00:00:00Z","timestamp":1508284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>The <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> fusion gene is caused by a translocation between chromosomes 9 and 22, resulting in an abnormal chromosome 22 (Philadelphia chromosome; Ph). Prior to the introduction of tyrosine kinase inhibitors (<jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>), the presence of <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> conferred a poor prognosis in patients with acute lymphoblastic leukaemia (<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>). We compared the survival of Ph+ and Ph\u2212<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> during the period when <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content>s were universally available in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> for Ph+<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>, using a Surveillance, Epidemiology, and End Results (<jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content>) Database analysis. A total of 2694 patients with pre\u2010B <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> (206 Ph+<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>; 2488 Ph\u2212<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content>) aged \u226518\u00a0years, who were diagnosed between 2010 and 2014, were identified in <jats:styled-content style=\"fixed-case\">SEER<\/jats:styled-content> registries. The median overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) was 32\u00a0months in Ph+<jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 18\u00a0months\u2010not reached) and 27\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 24\u201330\u00a0months) in Ph\u2212ALL (Log\u2010rank test <jats:italic>P<\/jats:italic>\u2010value 0\u00b734). Older age was associated with worse prognosis in both Ph+ALL and Ph\u2212ALL. Age\u2010adjusted <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> was inferior in Hispanics and African\u2010Americans compared to non\u2010Hispanic whites. Survival of pre\u2010B <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> shows continued improvement with time. Philadelphia chromosome status does not confer poor prognosis in pre\u2010B <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> in the <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> era: prognostic factors in pre\u2010B <jats:styled-content style=\"fixed-case\">ALL<\/jats:styled-content> should be re\u2010evaluated in the light of this finding.<\/jats:p>","DOI":"10.1111\/bjh.14953","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T03:12:44Z","timestamp":1508382764000},"page":"618-626","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["The presence of Philadelphia chromosome does not confer poor prognosis in adult pre\u2010B acute lymphoblastic leukaemia in the tyrosine kinase inhibitor era \u2013 a surveillance, epidemiology, and end results database analysis"],"prefix":"10.1111","volume":"179","author":[{"given":"Igwe 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