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Identification of persistent disease or relapse is most often the trigger to intensify or re\u2010initiate anti\u2010neoplastic therapy, respectively. In the current era of <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> treatment, this determination is mostly based on imaging and clinical evaluations, tools with imperfect sensitivity and specificity. The availability of minimal residual disease (<jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>) monitoring could transform treatment paradigms by allowing intensification of treatment in at\u2010risk patients or early intervention for impending relapse. Novel methods based on polymerase chain reaction and next\u2010generation sequencing are now being studied in <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> with promising results. This review outlines the current status of the field in the use of <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content> techniques for diffuse large B\u2010cell lymphoma, mantle cell lymphoma and follicular lymphoma. Specifically, we address their demonstrated and potential clinical utility in risk stratification, monitoring of remission status, and guiding interim and post\u2010treatment escalation. Future applications of these techniques could identify novel markers of <jats:styled-content style=\"fixed-case\">MRD<\/jats:styled-content>, improve initial treatment selection, guide treatment escalation or de\u2010escalation, and allow for real\u2010time monitoring of patterns of clonal evolution, which together could redefine <jats:styled-content style=\"fixed-case\">NHL<\/jats:styled-content> treatment paradigms.<\/jats:p>","DOI":"10.1111\/bjh.14996","type":"journal-article","created":{"date-parts":[[2017,10,27]],"date-time":"2017-10-27T01:52:48Z","timestamp":1509069168000},"page":"177-188","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Minimal residual disease in non\u2010Hodgkin lymphoma \u2013 current applications and future directions"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6998-2212","authenticated-orcid":false,"given":"Matthew 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