{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:09:10Z","timestamp":1760299750882,"version":"3.37.3"},"reference-count":30,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005972","name":"Deutsche Krebshilfe","doi-asserted-by":"publisher","award":["110884"],"award-info":[{"award-number":["110884"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To study if obesity is a risk factor in elderly patients (&gt;60\u00a0years) with aggressive B\u2010cell lymphoma, the outcomes of 576 elderly patients treated with rituximab in the <jats:styled-content style=\"fixed-case\">RICOVER<\/jats:styled-content>\u201060 trial were analysed in a retrospective study with regard to body mass index (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>) and gender. Of the 576 patients, 1% had low body weight (BMI\u00a0&lt;\u00a018\u00b75), 38% were normal weight (18\u00b75\u00a0\u2264\u00a0BMI\u00a0&lt;\u00a025), 42% were overweight (25\u00a0\u2264\u00a0BMI\u00a0&lt;\u00a030) and 19% were obese (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u00a0\u2265\u00a030). Event\u2010free (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>), progression\u2010free (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) according to <jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content> showed no significant differences for all and for male patients. <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7041), <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7038) and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7031) were significantly better for female non\u2010obese patients. A multivariate analysis adjusted for International Prognostic Index risk factors confirmed these results, with the following hazard ratios (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) for obesity (<jats:styled-content style=\"fixed-case\">BMI<\/jats:styled-content>\u00a0\u2265\u00a030) for <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>: all patients \u2013 1\u00b74\/1\u00b74\/1\u00b74 (not significant); male patients \u2013 1\u00b72\/1\u00b72\/1\u00b70 (not significant) and female patients \u2013 1\u00b77 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7032)\/1\u00b79 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7022)\/2\u00b70 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7017). In conclusion, obesity is a risk factor that influences treatment outcome in elderly female patients with aggressive B\u2010cell lymphoma treated with R\u2010<jats:styled-content style=\"fixed-case\">CHOP<\/jats:styled-content> (rituximab\u00a0+\u00a0cyclophosphamide, doxorubicin, vincristine, prednisolone). The inferior outcomes in obese female patients may be due to faster rituximab clearance in obese females.<\/jats:p>","DOI":"10.1111\/bjh.15029","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:42:00Z","timestamp":1511970120000},"page":"236-245","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Obesity negatively impacts outcome in elderly female patients with aggressive B\u2010cell lymphomas treated with R\u2010CHOP: results from prospective trials of the German high grade non\u2010Hodgkin's lymphoma trial group"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1412-3274","authenticated-orcid":false,"given":"K.","family":"Hohloch","sequence":"first","affiliation":[{"name":"Haematology and Oncology Kantonspital Graub\u00fcnden Chur Switzerland"},{"name":"Department of Haematology and Medical Oncology University Medical Centre UMG Georg 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