{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T05:56:45Z","timestamp":1790834205736,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81621001"],"award-info":[{"award-number":["81621001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770191"],"award-info":[{"award-number":["81770191"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370666"],"award-info":[{"award-number":["81370666"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Epstein\u2013Barr virus (EBV) reactivation remains a life\u2010threatening complication in recipients of a haploidentical haematopoietic stem cell transplantation (haploHSCT). Reconstitution of adaptive T lymphocytes is generally compromised at the early stages following transplant, suggesting an important role of other effector cells in preventing EBV infection. Our previous studies demonstrated that recovery of CD4<jats:sup>\u2212<\/jats:sup>CD8<jats:sup>\u2212<\/jats:sup> T cells negatively correlated with EBV reactivation after haploHSCT. In this prospective study on 132 adult patients with haematopoietic malignancy, recovery of T\u2010cell subpopulations was characterized post\u2010haploHSCT. We showed that the median counts of peripheral V\u03b42 cells were continuously lower in recipients with EBV reactivation compared with controls at 30, 60 and 90\u00a0days after haploHSCT (<jats:italic>P<\/jats:italic> values: 0\u00b7006, &lt;0\u00b7001 and 0\u00b7019, respectively). Landmark study further indicated that the cumulative incidence of EBV reactivation was significantly decreased in recipients with higher day\u201030\u00a0V\u03b42 counts. Activation of V\u03b42 cells upon EBV reactivation was accompanied by an induction of cell apoptosis. Cytotoxic effect of V\u03b42 cells on EBV\u2010infected cells was confirmed by <jats:italic>in\u00a0vitro<\/jats:italic> experiments. Together, our findings uncovered a significant correlation of recovered V\u03b42 with EBV reactivation following haploHSCT. These results will help to better understand the intrinsic anti\u2010virus immunity and develop \u03b3\u03b4 T\u2010based therapy strategies after haematopoietic transplantation.<\/jats:p>","DOI":"10.1111\/bjh.15037","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T16:36:36Z","timestamp":1514046996000},"page":"276-285","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Inverse correlation of V\u03b42<sup>+<\/sup> T\u2010cell recovery with <scp>EBV<\/scp> reactivation after haematopoietic stem cell transplantation"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6437-4330","authenticated-orcid":false,"given":"Jiangying","family":"Liu","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key laboratory of Hematopoietic Stem Cell Transplantation Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenguang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying\u2010Jun","family":"Chang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Wang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0245-6792","authenticated-orcid":false,"given":"Xiao\u2010Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengfan","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-6643","authenticated-orcid":false,"given":"Xiao\u2010Jun","family":"Huang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Hematology Beijing Key laboratory of Hematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-09-599423"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/bmt.2016.238","article-title":"Association of Epstein\u2010Barr virus reactivation with the recovery of CD4\/CD8 double\u2010negative T lymphocytes after haploidentical hematopoietic stem cell transplantation","volume":"52","author":"Bian Z.","year":"2017","journal-title":"Bone Marrow 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