{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:09:36Z","timestamp":1773076176033,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005156","name":"Alexander von Humboldt-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Predominantly diffuse t(14;18) negative follicular lymphoma (<jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>) with 1p36 deletion shows distinctive clinical, morphological and molecular features that distinguish it from classical <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. In order to investigate whether it possesses a unique mutation profile, we performed whole exome sequencing of six well\u2010characterised cases. Our analysis showed that the mutational landscape of this subtype is largely distinct from classical <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>. It appears to harbour several recurrent mutations, affecting <jats:italic><jats:styled-content style=\"fixed-case\">STAT<\/jats:styled-content>6, <jats:styled-content style=\"fixed-case\">CREBBP<\/jats:styled-content><\/jats:italic> and basal membrane protein genes with high frequency. Our data support the view that this <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content> subtype should be considered a separate entity from classical <jats:styled-content style=\"fixed-case\">FL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15041","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T15:39:15Z","timestamp":1511969955000},"page":"391-394","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["The exomic landscape of t(14;18)\u2010negative diffuse follicular lymphoma with 1p36 deletion"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6203-7966","authenticated-orcid":false,"given":"Alberto","family":"Zam\u00f2","sequence":"first","affiliation":[{"name":"Department of Diagnostics and Public Health University of Verona Verona Italy"},{"name":"Alexander von Humboldt Fellow Institute of Pathology University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Pischimarov","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Comprehensive Cancer Center Mainfranken (CCC MF) University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heike","family":"Horn","sequence":"additional","affiliation":[{"name":"Dr Margarete Fischer\u2010Bosch\u2010Institute for Clinical Pharmacology Stuttgart Germany"},{"name":"University of T\u00fcbingen T\u00fcbingen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-6793","authenticated-orcid":false,"given":"German","family":"Ott","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Robert\u2010Bosch\u2010Krankenhaus Stuttgart Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Rosenwald","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Comprehensive Cancer Center Mainfranken (CCC MF) University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen","family":"Leich","sequence":"additional","affiliation":[{"name":"Institute of Pathology and Comprehensive Cancer Center Mainfranken (CCC MF) University of W\u00fcrzburg W\u00fcrzburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/10428194.2016.1173212"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-05-500595"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14664"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.06.043"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgv026"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-07-168682"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2014.8"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(15)00169-2"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2016.51"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1182\/blood-2015-08-665141","article-title":"Sugar\u2010coated signaling in follicular lymphoma","volume":"126","author":"Strout M.P.","year":"2015","journal-title":"Blood"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2013.54"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2003305"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-06-582650"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.15041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,28]],"date-time":"2023-09-28T00:44:36Z","timestamp":1695861876000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/bjh.15041"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15041","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]},"assertion":[{"value":"2017-08-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}