{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:55:45Z","timestamp":1791910545932,"version":"4.3.4"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T00:00:00Z","timestamp":1513641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"Summary<\/jats:title>Primary mediastinal (thymic) large B\u2010cell lymphoma (PMBCL<\/jats:styled-content>) is an uncommon subtype of non\u2010Hodgkin lymphoma (NHL<\/jats:styled-content>) that presents with a mediastinal mass and has unique clinicopathological features. Historically, patients with PMBCL<\/jats:styled-content> were treated with R\u2010CHOP<\/jats:styled-content> (rituximab, cyclophosphamide, doxorubicin, vincristine, prednisone) chemotherapy\u00a0\u00b1\u00a0involved field radiation. Since a phase II<\/jats:styled-content> trial, published in April 2013, demonstrated excellent results using dose\u2010adjusted (DA<\/jats:styled-content>) R\u2010EPOCH<\/jats:styled-content> (rituximab, etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin), this treatment has gained popularity. We performed a retrospective, multicentre analysis of patients aged \u226518\u00a0years with PMBCL<\/jats:styled-content> since January 2011. Patients were stratified by frontline regimen, R\u2010CHOP <\/jats:styled-content>versus <\/jats:italic>DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content>. 132 patients were identified from 11 contributing centres (56 R\u2010CHOP<\/jats:styled-content> and 76 DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content>). The primary outcome was overall survival. Secondary outcomes included progression\u2010free survival, complete response (CR<\/jats:styled-content>) rate, and rates of treatment\u2010related complications. Demographic characteristics were similar in both groups. DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content> use increased after April 2013 (79% vs. 45%, P<\/jats:italic>\u00a0<\u00a00\u00b7001), and there was less radiation use after DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content> (13% vs. 59%, P<\/jats:italic>\u00a0<\u00a00\u00b7001). While CR<\/jats:styled-content> rates were higher with DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content> (84% vs. 70%, P<\/jats:italic>\u00a0=\u00a00\u00b7046), these patients were more likely to experience treatment\u2010related toxicities. At 2\u00a0years, 89% of R\u2010CHOP<\/jats:styled-content> patients and 91% of DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content> patients were alive. To our knowledge, this represents the largest series comparing outcomes of R\u2010CHOP<\/jats:styled-content> to DA<\/jats:styled-content>\u2010R\u2010EPOCH<\/jats:styled-content> for PMBCL<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15051","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T10:12:38Z","timestamp":1513678358000},"page":"534-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["R\u2010CHOP <\/scp>versus<\/i> dose\u2010adjusted R\u2010EPOCH<\/scp> in frontline management of primary mediastinal B\u2010cell lymphoma: a multi\u2010centre analysis"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4336-1071","authenticated-orcid":false,"given":"Nirav N.","family":"Shah","sequence":"first","affiliation":[{"name":"Division of Hematology & Oncology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aniko","family":"Szabo","sequence":"additional","affiliation":[{"name":"Division of Biostatistics Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott F.","family":"Huntington","sequence":"additional","affiliation":[{"name":"Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8216-3457","authenticated-orcid":false,"given":"Narendranath","family":"Epperla","sequence":"additional","affiliation":[{"name":"Division of Hematology & Oncology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishitha","family":"Reddy","sequence":"additional","affiliation":[{"name":"Vanderbilt University Ingram Cancer Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siddhartha","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Kansas University Medical Center Kansas City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Vose","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia","family":"Obiozor","sequence":"additional","affiliation":[{"name":"Kansas University Medical Center Kansas City USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fahad","family":"Faruqi","sequence":"additional","affiliation":[{"name":"Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra E.","family":"Kovach","sequence":"additional","affiliation":[{"name":"Vanderbilt University Ingram Cancer Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5362-2469","authenticated-orcid":false,"given":"Luciano J.","family":"Costa","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-3798","authenticated-orcid":false,"given":"Ana C.","family":"Xavier","sequence":"additional","affiliation":[{"name":"Children's of Alabama University of Alabama at Birmingham Birmingham AL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Okal","sequence":"additional","affiliation":[{"name":"West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abraham S.","family":"Kanate","sequence":"additional","affiliation":[{"name":"West Virginia University Morgantown WV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nilanjan","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Levine Cancer Institute\/Carolinas HealthCare System Charlotte North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-5185","authenticated-orcid":false,"given":"Mohamed A.","family":"Kharfan\u2010Dabaja","sequence":"additional","affiliation":[{"name":"H. Lee Moffitt Cancer Center and Research Institute Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Strelec","sequence":"additional","affiliation":[{"name":"University of Pennsylvania Philadelphia PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5372-510X","authenticated-orcid":false,"given":"Mehdi","family":"Hamadani","sequence":"additional","affiliation":[{"name":"Division of Hematology & Oncology Medical College of Wisconsin Milwaukee WI USA"},{"name":"Center of International Bone Marrow Transplant Research (CIBMTR) Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy S.","family":"Fenske","sequence":"additional","affiliation":[{"name":"Division of Hematology & Oncology Medical College of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7592-9023","authenticated-orcid":false,"given":"Oscar","family":"Calzada","sequence":"additional","affiliation":[{"name":"Emory University\u2010Winship Cancer Institute Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathon B.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Emory University\u2010Winship Cancer Institute Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Chavez","sequence":"additional","affiliation":[{"name":"H. 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