{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T12:22:32Z","timestamp":1789042952861,"version":"build-2803163510"},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,21]],"date-time":"2017-12-21T00:00:00Z","timestamp":1513814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>To determine whether pre\u2010treatment neutrophil\/lymphocyte (<jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content>) or platelet\/lymphocyte ratios (<jats:styled-content style=\"fixed-case\">PLR<\/jats:styled-content>) are predictive for progression in early\u2010stage classical Hodgkin lymphoma (<jats:styled-content style=\"fixed-case\">cHL<\/jats:styled-content>), we derived <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PLR<\/jats:styled-content> values for 338 stage I\/<jats:styled-content style=\"fixed-case\">II cHL<\/jats:styled-content> patients and appropriate cut\u2010off point values to define progression. Two\u2010year freedom from progression (<jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content>) for patients with <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> \u22656\u00b74 was 82\u00b72% vs. 95\u00b77% with <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> &lt;6\u00b74 (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Similarly, 2\u2010year <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content> was 84\u00b73% for patients with <jats:styled-content style=\"fixed-case\">PLR<\/jats:styled-content> \u2265266\u00b72 vs. 96\u00b71% with <jats:styled-content style=\"fixed-case\">PLR<\/jats:styled-content> &lt;266\u00b72 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003). On univariate analysis, both <jats:styled-content style=\"fixed-case\">NLR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PLR<\/jats:styled-content> were significantly associated with worse <jats:styled-content style=\"fixed-case\">FFP<\/jats:styled-content> (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001). On multivariate analysis, <jats:styled-content style=\"fixed-case\">PLR<\/jats:styled-content> remained a significant, independent prognostic factor (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001).<\/jats:p>","DOI":"10.1111\/bjh.15054","type":"journal-article","created":{"date-parts":[[2017,12,23]],"date-time":"2017-12-23T16:41:10Z","timestamp":1514047270000},"page":"545-549","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Pre\u2010treatment neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio are prognostic of progression in early stage classical Hodgkin lymphoma"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9378-4585","authenticated-orcid":false,"given":"Jay P.","family":"Reddy","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mike","family":"Hernandez","sequence":"additional","affiliation":[{"name":"Department of Biostatistics The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jillian R.","family":"Gunther","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bouthaina S.","family":"Dabaja","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey V.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX 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Pharmacy Services University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace L.","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chelsea C.","family":"Pinnix","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-6967","authenticated-orcid":false,"given":"Sarah A.","family":"Milgrom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology The University of Texas MD Anderson Cancer Center Houston TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Abou 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