{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:08:47Z","timestamp":1791256127828,"version":"4.1.0"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,12,12]],"date-time":"2017-12-12T00:00:00Z","timestamp":1513036800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Perioperative bleeding is a major concern in patients with factor VII (FVII) deficiency. Evaluating data of 95 FVII\u2010deficient patients undergoing 110 surgical procedures (61 major, 49 minor), we assessed the impact of type of surgery, bleeding phenotype and FVII coagulant activity (FVII:C) levels on perioperative replacement therapy (RT). Compared to those with higher FVII:C levels, patients with &lt;3% FVII:C received a higher number of RT doses (8 vs. 2, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7003) for a longer RT duration (3\u00a0days vs. 1\u00a0day, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), with no difference in RT dose. Similarly, patients with a history of major bleeds received a higher number of RT doses (8\u00b75 vs. 2\u20133, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013) for a longer RT duration (2\u00a0days vs. 1\u00a0day, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) as compared to those with a history of minor bleeds or to asymptomatic patients. No difference in RT was found among major and minor surgical procedures. Overall, multivariate analysis showed that history of major bleeding was the only independent predictor of number of RT doses (\u03b2\u00a0=\u00a00\u00b7352, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001) and RT duration (\u03b2\u00a0=\u00a00\u00b7405, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018). Overall, a \u224820\u00a0\u03bcg\/kg perioperative RT was efficacious in 95\u00b75% of cases. The infusion should be repeated \u22488 times in high\u2010risk subsets (i.e. patients with a history of major bleeding).<\/jats:p>","DOI":"10.1111\/bjh.15055","type":"journal-article","created":{"date-parts":[[2017,12,13]],"date-time":"2017-12-13T02:13:18Z","timestamp":1513131198000},"page":"563-570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Role of clinical and laboratory parameters for treatment choice in patients with inherited <scp>FVII<\/scp> deficiency undergoing surgical procedures: evidence from the <scp>STER<\/scp> registry"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-3819","authenticated-orcid":false,"given":"Matteo N. D.","family":"Di Minno","sequence":"first","affiliation":[{"name":"Department of Advanced Biomedical Sciences Federico II University Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariasanta","family":"Napolitano","sequence":"additional","affiliation":[{"name":"Haematology Unit Thrombosis and Hemostasis Reference Regional Center University of Palermo Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Dolce","sequence":"additional","affiliation":[{"name":"Istituto Nazionale di Statistica Palermo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guglielmo","family":"Mariani","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology University of Westminster London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the STER Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2011.04291.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1538-7836.2004.00922.x"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH12-10-0740"},{"key":"e_1_2_8_5_1","first-page":"72","article-title":"Inherited factor VII deficiency and surgery: clinical data are the best criteria to predict the risk of bleeding","volume":"117","author":"Giansily\u2010Blaizot M.","year":"2002","journal-title":"British Journal of Haematology"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/B978-1-4557-2296-9.00036-1","volume-title":"Consultative Hemostasis and Thrombosis","author":"Kitchens C.S.","year":"2013"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165104"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-02-0595"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1225762"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH04-10-0650"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2010.08287.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2516.2012.02751.x"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03545.x"}],"container-title":["British Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fbjh.15055","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bjh.15055","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T21:45:47Z","timestamp":1695678347000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bjh.15055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,12]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,2]]}},"alternative-id":["10.1111\/bjh.15055"],"URL":"https:\/\/doi.org\/10.1111\/bjh.15055","archive":["Portico"],"relation":{},"ISSN":["0007-1048","1365-2141"],"issn-type":[{"value":"0007-1048","type":"print"},{"value":"1365-2141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,12]]},"assertion":[{"value":"2017-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-10-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-12-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}