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The complement system is integral to innate immunity and shares numerous interactions with components of the haemostatic pathway, helping to maintain physiological equilibrium. The term \u2018immunothrombosis\u2019 was introduced in 2013 to embrace this process, and has become an area of much recent interest. What is less apparent in the literature however is an appreciation of the clinical manifestations of the coagulation\u2010complement interaction and the consequences of dysregulation of either system, as seen in many inflammatory and thrombotic disease states, such as sepsis, trauma, atherosclerosis, antiphospholipid syndrome (<jats:styled-content style=\"fixed-case\">APS<\/jats:styled-content>), paroxysmal nocturnal haemoglobinuria (<jats:styled-content style=\"fixed-case\">PNH<\/jats:styled-content>) and some thrombotic microangiopathies to name a few. The growing appreciation of this immunothrombotic phenomenon will foster the drive for novel therapies in these disease states, including anticoagulants as immunomodulators and targeted molecular therapies.<\/jats:p>","DOI":"10.1111\/bjh.15062","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T10:38:56Z","timestamp":1513679936000},"page":"782-798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":161,"title":["Haemostasis and innate immunity \u2013 a complementary relationship"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4265-4291","authenticated-orcid":false,"given":"Charithani B.","family":"Keragala","sequence":"first","affiliation":[{"name":"Molecular Neurotrauma and Haemostasis Australian Centre for Blood Diseases Monash University Melbourne Vic. 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