{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T06:15:17Z","timestamp":1789884917801,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T00:00:00Z","timestamp":1516752000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH 1R01HL079937"],"award-info":[{"award-number":["NIH 1R01HL079937"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["UL1 RR024989"],"award-info":[{"award-number":["UL1 RR024989"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Asthma is associated with higher rates of acute chest syndrome (<jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>) and vaso\u2010occlusive pain episodes among children with sickle cell anaemia (<jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>). Aeroallergen sensitization is a risk factor for asthma. We hypothesized that aeroallergen sensitization is associated with an increased incidence of hospitalizations for <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> and pain. Participants in a multicentre, longitudinal cohort study, aged 4\u201318\u00a0years with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>, underwent skin prick testing to ten aeroallergens. <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> and pain episodes were collected from birth until the end of the follow\u2010up period. The number of positive skin tests were tested for associations with prospective rates of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> and pain. Multivariable models demonstrated additive effects of having positive skin tests on future rates of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> (incidence rate ratio (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content>) for each positive test 1\u00b723, 95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 1\u00b711\u20131\u00b736, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00\u00b7001). Aeroallergen sensitization was not associated with future pain (<jats:styled-content style=\"fixed-case\">IRR<\/jats:styled-content> 1\u00b714, 95%<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 0\u00b797\u20131\u00b733, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b711). Our study demonstrated that children with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content> and aeroallergen sensitization are at increased risk for future <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content>. Future research is needed to determine whether identification of specific sensitizations and allergen avoidance and treatment reduce the risk of <jats:styled-content style=\"fixed-case\">ACS<\/jats:styled-content> for children with <jats:styled-content style=\"fixed-case\">SCA<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15076","type":"journal-article","created":{"date-parts":[[2018,1,24]],"date-time":"2018-01-24T12:18:41Z","timestamp":1516796321000},"page":"571-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Aeroallergen sensitization predicts acute chest syndrome in children with sickle cell anaemia"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6691-816X","authenticated-orcid":false,"given":"Shaina M.","family":"Willen","sequence":"first","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology Vanderbilt\u2010Meharry Center for Excellence in Sickle Cell Disease Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Rodeghier","sequence":"additional","affiliation":[{"name":"Rodeghier Consultants Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C.","family":"Strunk","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Allergy, Immunology, and Pulmonary Medicine Washington University School of Medicine St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard B.","family":"Bacharier","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Allergy, Immunology, and Pulmonary Medicine Washington University School of Medicine St Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol L.","family":"Rosen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Pulmonary, Allergy\/Immunology and Sleep University Hospitals\u2010Cleveland Medical Center Rainbow Babies and Children's Hospitals Cleveland OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenella J.","family":"Kirkham","sequence":"additional","affiliation":[{"name":"Developmental Neurosciences Unit UCL Great Ormond Street Institute of Child Health London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R.","family":"DeBaun","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Hematology\/Oncology Vanderbilt\u2010Meharry Center for Excellence in Sickle Cell Disease Vanderbilt University Medical Center Nashville TN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn T.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Division of Pediatric Pulmonary &amp; Allergy Boston University School of Medicine Boston MA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.12.1114"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2015.03.001"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.07.056"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.13090"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-01-011072"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11213"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198902023200502"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2004.04.010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V84.2.643.643"},{"key":"e_1_2_7_11_1","unstructured":"Centers for Disease Control and Prevention (CDC). (2008)Laboratory Procedure Manual for NHANES 2005\u20132006 data\u2010 Specific IgE\/Total IgE Allergens in Serum. 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