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This bleeding disorder can be treated with platelet transfusion therapy, but some patients will be immunized and begin to form anti\u2010human leucocyte antigen (<jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content>) and\/or anti\u2010\u03b1<jats:styled-content style=\"fixed-case\"><jats:sub>II<\/jats:sub><\/jats:styled-content><jats:sub>b<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> antibodies. These antibodies can bind and interfere with the function of the transfused platelets, rendering treatment ineffective. However, platelet transfusion refractoriness attributable to <jats:styled-content style=\"fixed-case\">HLA<\/jats:styled-content> antibodies may be managed by the selection of compatible donors, although they are not always readily available, particularly in an emergency. Thus, anti\u2010\u03b1<jats:styled-content style=\"fixed-case\"><jats:sub>II<\/jats:sub><\/jats:styled-content><jats:sub>b<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> antibodies represent one of the most severe complications in <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content>. Both genetic and environmental factors may contribute to the risk of anti\u2010\u03b1<jats:styled-content style=\"fixed-case\"><jats:sub>II<\/jats:sub><\/jats:styled-content><jats:sub>b<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> development, but the underlying pathogenic mechanisms are still unknown. This\u00a0review\u00a0will summarize the current knowledge of the risk factors for development of anti\u2010\u03b1<jats:styled-content style=\"fixed-case\"><jats:sub>II<\/jats:sub><\/jats:styled-content><jats:sub>b<\/jats:sub>\u03b2<jats:sub>3<\/jats:sub> antibodies in patients with <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> and discuss how these findings may influence the clinical management of patients.<\/jats:p>","DOI":"10.1111\/bjh.15087","type":"journal-article","created":{"date-parts":[[2018,4,3]],"date-time":"2018-04-03T04:17:28Z","timestamp":1522729048000},"page":"173-182","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Anti\u2010\u03b1<sub>IIb<\/sub>\u03b2<sub>3<\/sub> immunization in Glanzmann thrombasthenia: review of literature and treatment 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