{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:53:30Z","timestamp":1792511610984,"version":"4.5.0"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,1,7]],"date-time":"2018-01-07T00:00:00Z","timestamp":1515283200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:p>We report a multicentre retrospective study that analysed clinical characteristics and outcomes in 117 patients with primary plasma cell leukaemia (<jats:styled-content style=\"fixed-case\">pPCL<\/jats:styled-content>) treated at the participating institutions between January 2006 and December 2016. The median age at the time of <jats:styled-content style=\"fixed-case\">pPCL<\/jats:styled-content> diagnosis was 61\u00a0years. Ninety\u2010eight patients were treated with novel agents, with an overall response rate of 78%. Fifty\u2010five patients (64%) patients underwent upfront autologous stem cell transplantation (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>). The median follow\u2010up time was 50\u00a0months (95% confidence interval [<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>] 33; 76), with a median overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) for the entire group of 23\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 15; 34). The median <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> time in patients who underwent upfront <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> was 35\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 24\u00b73; 46) as compared to 13\u00a0months (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 6\u00b73; 35\u00b78) in patients who did not receive <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>=<jats:italic>\u00a0<\/jats:italic>0\u00b7001). Multivariate analyses identified age \u226560\u00a0years, platelet count \u2264100\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l and peripheral blood plasma cell count \u226520\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l as independent predictors of worse survival. The median <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> in patients with 0, 1 or 2\u20133 of these risk factors was 46, 27 and 12\u00a0months, respectively (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b7001). Our findings support the use of novel agents and <jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content> as frontline treatment in patients with <jats:styled-content style=\"fixed-case\">pPCL<\/jats:styled-content>. The constructed prognostic score should be independently validated.<\/jats:p>","DOI":"10.1111\/bjh.15092","type":"journal-article","created":{"date-parts":[[2018,1,10]],"date-time":"2018-01-10T04:55:21Z","timestamp":1515560121000},"page":"831-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9796-8365","authenticated-orcid":false,"given":"Artur","family":"Jurczyszyn","sequence":"first","affiliation":[{"name":"Jagiellonian University Medical College Cracow Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Radocha","sequence":"additional","affiliation":[{"name":"4th Department of Medicine \u2013 Haematology Charles University Hospital Hradec Kralove Hradec Kralove Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio","family":"Davila","sequence":"additional","affiliation":[{"name":"Hospital Universitario de Salamanca Salamanca Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Fiala","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine Saint Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Gozzetti","sequence":"additional","affiliation":[{"name":"Le Scotte Hospital Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Grz\u0105\u015bko","sequence":"additional","affiliation":[{"name":"Department of Haematology St John\u2018s Cancer Centre Lublin Poland"},{"name":"Department of Experimental Haematology Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pawe\u0142","family":"Robak","sequence":"additional","affiliation":[{"name":"Department of Haematology Medical University of Lodz Copernicus Memorial Hospital \u0141\u00f3d\u017a Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iwona","family":"Hus","sequence":"additional","affiliation":[{"name":"Department of Haematology and Bone Marrow Transplantation Medical University of Lublin Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Waszczuk\u2010Gajda","sequence":"additional","affiliation":[{"name":"Department of Haematology, Oncology and Internal Medicine Warsaw Medical University Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Guzicka\u2010Kazimierczak","sequence":"additional","affiliation":[{"name":"Department of Haematology Pomeranian Medical University Szczecin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erden","family":"Atilla","sequence":"additional","affiliation":[{"name":"Haematology Department and Bone Marrow Transplantation Unit Ankara University Medical School Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-8618","authenticated-orcid":false,"given":"Giuseppe","family":"Mele","sequence":"additional","affiliation":[{"name":"Ospedale A. Perrino, Haemetaology Brindisi Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waldemar","family":"Sawicki","sequence":"additional","affiliation":[{"name":"Dept. of Internal Medicine and Haematology Military Institute of Medicine Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Jayabalan","sequence":"additional","affiliation":[{"name":"Weill Cornell Medical College New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Charli\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Haematology Nicolaus Copernicus Hospital Torun Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agoston G.","family":"Szabo","sequence":"additional","affiliation":[{"name":"Department of Medicine Section\u00a0of Haematology Vejle 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