{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T22:12:48Z","timestamp":1789423968801,"version":"build-2803163510"},"reference-count":19,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006662","name":"National Institute on Handicapped Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006662","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>This study aimed to estimate the diagnostic utility of biomarkers for suspected venous thromboembolism (<jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>) in pregnancy and the puerperium. Research nurses\/midwives collected blood samples from 310 pregnant\/postpartum women with suspected pulmonary emboli (<jats:styled-content style=\"fixed-case\">PE<\/jats:styled-content>) and 18 with diagnosed deep vein thrombosis (<jats:styled-content style=\"fixed-case\">DVT<\/jats:styled-content>). <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> was diagnosed using imaging, treatment and adverse outcome data. Primary analysis was limited to women with conclusive imaging (36 with <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>, 247 without). The area under the curve (<jats:styled-content style=\"fixed-case\">AUC<\/jats:styled-content>) for each biomarker was: activated partial thromboplastin time 0\u00b7669 (95% confidence interval 0\u00b7570\u20130\u00b7768), B\u2010type natriuretic peptide 0\u00b7549 (0\u00b7453\u20130\u00b7645), C\u2010reactive protein 0\u00b7542 (0\u00b7445\u20130\u00b7639), Clauss fibrinogen 0\u00b7589 (0\u00b7476\u20130\u00b7701), D\u2010Dimer (by enzyme\u2010linked immunosorbent assay) 0\u00b7668 (0\u00b7561\u20130\u00b7776), near\u2010patient D\u2010Dimer 0\u00b7651 (0\u00b7545\u20130\u00b7758), mid\u2010regional pro\u2010atrial natriuretic peptide 0\u00b7524 (0\u00b7418\u20130\u00b7630), prothrombin fragment 1\u00a0+\u00a02 0\u00b7562 (0\u00b7462\u20130\u00b7661), plasmin\u2010antiplasmin complexes 0\u00b7639 (0\u00b7536\u20130\u00b7742), prothombin time 0\u00b7613 (0\u00b7508\u20130\u00b7718), thrombin generation lag time 0\u00b7702 (0\u00b7598\u20130\u00b7806), thrombin generation endogenous potential 0\u00b7559 (0\u00b7437\u20130\u00b7681), thrombin generation peak 0\u00b7596 (0\u00b7478\u20130\u00b7715), thrombin generation time to peak 0\u00b7655 (0\u00b7541\u20130\u00b7769), soluble tissue factor 0\u00b7531 (0\u00b7424\u20130\u00b7638) and serum troponin 0\u00b7597 (0\u00b7499\u20130\u00b7695). No diagnostically useful threshold for diagnosing or ruling out <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content> was identified. In pregnancy and the puerperium, conventional and candidate biomarkers have no utility either for their negative or positive predictive value in the diagnosis of <jats:styled-content style=\"fixed-case\">VTE<\/jats:styled-content>.<\/jats:p>","DOI":"10.1111\/bjh.15102","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T11:17:18Z","timestamp":1516706238000},"page":"694-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["The Di<scp>PEP<\/scp> (Diagnosis of <scp>PE<\/scp> in Pregnancy) biomarker study: An observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium"],"prefix":"10.1111","volume":"180","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-0774","authenticated-orcid":false,"given":"Beverley J","family":"Hunt","sequence":"first","affiliation":[{"name":"Guy's &amp; St Thomas's NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiran","family":"Parmar","sequence":"additional","affiliation":[{"name":"Guy's &amp; St Thomas's NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberley","family":"Horspool","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Shephard","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Nelson\u2010Piercy","sequence":"additional","affiliation":[{"name":"Guy's &amp; St Thomas's NHS Foundation Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Goodacre","sequence":"additional","affiliation":[{"name":"School of Health and Related Research University of Sheffield Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the DiPEP research group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.12.9917"},{"issue":"8","key":"e_1_2_9_3_1","first-page":"CD010864","article-title":"D\u2010dimer test for excluding the diagnosis of pulmonary embolism","author":"Crawford F.","year":"2016","journal-title":"Cochrane Database Systematic Review"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000054"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443610802649045"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/emermed-2014-203871"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.05.024"},{"key":"e_1_2_9_8_1","doi-asserted-by":"crossref","first-page":"3561675","DOI":"10.1155\/2016\/3561675","article-title":"Large D\u2010Dimer fluctuation in normal pregnancy: a longitudinal cohort study of 4,117 Samples from 714 Healthy Danish Women","volume":"2016","author":"Hedengran K.K.","year":"2016","journal-title":"Obstetrics and Gynecology International"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30885-1"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.03.024"},{"key":"e_1_2_9_11_1","volume-title":"Saving Lives, Improving Mothers\u2019 Care \u2010 Surveillance of Maternal Deaths in the UK 2012\u201014 and Lessons Learned to Inform Maternity Care From the UK and Ireland Confidential Enquiries Into Maternal Deaths and Morbidity 2009\u201014","author":"Knight M.","year":"2016"},{"key":"e_1_2_9_12_1","first-page":"3033","article-title":"ESC guidelines on the diagnosis and management of acute pulmonary embolism","volume":"2014","author":"Konstantinides S.V.","year":"2014","journal-title":"European Heart Journal"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2009.09.005"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201108-1575ST"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.11.1061"},{"key":"e_1_2_9_16_1","doi-asserted-by":"crossref","unstructured":"National Institute for Health and Care Excellence.NICE clinical guideline 144: Venous thromboembolic diseases: the management of venous thromboembolic diseases and the role of thrombophilia testing.2012. 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