{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T10:51:32Z","timestamp":1780483892396,"version":"3.54.1"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T00:00:00Z","timestamp":1522368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Systemic anaplastic lymphoma kinase positive (<jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>+) anaplastic large cell lymphoma with extranodal involvement (<jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>\u2010E) is a rare form of non\u2010Hodgkin lymphoma. No large study in the literature has compared the survival outcomes among different primary extranodal sites of involvement in <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>\u2010E. We identified 1306 patients with <jats:styled-content style=\"fixed-case\">ALK<\/jats:styled-content>+ <jats:styled-content style=\"fixed-case\">ALCL<\/jats:styled-content>\u2010E diagnosed between 2004 and 2014 in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> National Cancer Database, among whom 387 had primary extranodal site in the chest\/abdomen\/pelvis, 103 in the bone, 62 in the central nervous system, 134 in the head and neck and 620 in the cutaneous\/soft tissue. Younger age, lower Charlson\u2010Deyo score, lower clinical stage, receipt of chemotherapy and receipt of radiotherapy were predictors of longer overall survival. Patients with extranodal involvement of central nervous system and chest\/abdomen\/pelvis had shorter overall survival than those with involvement of head and neck, bone, and cutaneous\/subcutaneous tissue after adjusting for confounding variables. We recommend treating these patients upfront with more aggressive therapy.<\/jats:p>","DOI":"10.1111\/bjh.15145","type":"journal-article","created":{"date-parts":[[2018,3,30]],"date-time":"2018-03-30T23:34:08Z","timestamp":1522452848000},"page":"196-204","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Disease site as a determinant of survival outcome in patients with systemic anaplastic lymphoma kinase positive anaplastic large cell lymphoma with extranodal involvement: an analysis of 1306 cases from the <scp>US<\/scp> National Cancer Database"],"prefix":"10.1111","volume":"181","author":[{"given":"Kevin A.","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Xiangya Hospital Central South University Changsha China"},{"name":"Department of Molecular Biophysics and Biochemistry Yale School of Medicine New Haven CT 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