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TCD categories included: normal (&lt;170\u00a0cm\/s), conditional (170\u2013199\u00a0cm\/s) and abnormal (\u2265200\u00a0cm\/s) based on TAMV in distal internal carotid artery (dICA), middle cerebral artery (MCA), internal carotid bifurcation, anterior and posterior cerebral arteries. Of 358 children with sickle cell anaemia (SCA) examined, the mean age (\u00b1standard deviation) was 7\u00b74\u00a0\u00b1\u00a02\u00b77\u00a0years; 13\u00b71% and 6\u00b77% had conditional and abnormal velocities, respectively. Children with abnormal TCD velocities had higher prevalence of prior stroke (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7006). Increased TAMV was associated with younger age (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), lower weight (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7001), height (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7007) and oxygen saturation (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005). There was no association of TAMV with height\u2010age or body mass index (BMI) <jats:italic>z<\/jats:italic>\u2010scores. Adjusting for gender, BMI <jats:italic>z<\/jats:italic>\u2010score, age, previous stroke and oxygen saturation, mean corpuscular volume (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) and reticulocyte count (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7013) were positively associated with TAMV, while haemoglobin concentration (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7009) was negatively associated. There was good agreement [99%; weighted Kappa 0\u00b798 (95% confidence interval 0\u00b789\u20131), <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b70001] in TCD classification using data from five vessels <jats:italic>versus<\/jats:italic> two vessels (dICA and MCA). Haematological variables, rather than nutritional status, may be useful markers that identify high\u2010risk children with SCA.<\/jats:p>","DOI":"10.1111\/bjh.15162","type":"journal-article","created":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T08:16:39Z","timestamp":1520237799000},"page":"242-251","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Transcranial Doppler velocity among Jamaican children with sickle cell anaemia: determining the significance of haematological values and nutrition"],"prefix":"10.1111","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3535-0911","authenticated-orcid":false,"given":"Angela E.","family":"Rankine\u2010Mullings","sequence":"first","affiliation":[{"name":"Sickle Cell Unit Caribbean Institute for Health Research University of the West Indies Kingston 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