{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T12:45:10Z","timestamp":1793105110502,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100005I"],"award-info":[{"award-number":["HHSN268201100005I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HHSN268201100004I"],"award-info":[{"award-number":["HHSN268201100004I"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Despite the significance of red blood cell (<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content>) alloimmunization, the lack of standardized registries in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content> has prevented the completion of large studies. Data from 3\u00b75\u00a0years of the Recipient Epidemiology and Donor Evaluation Study\u2010III (<jats:styled-content style=\"fixed-case\">REDS<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">III<\/jats:styled-content>) recipient database, containing information from 12 hospitals, were studied. A <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> alloantibody responder had an antibody identified at any point during the study, and a non\u2010responder had a negative antibody screen at least 15\u00a0days post\u2010<jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> transfusion. Demographics, blood type, <jats:styled-content style=\"fixed-case\">ICD<\/jats:styled-content>9\/10 codes, and other potential correlates were evaluated. Of 319\u00a0177 (2\u00b707%) screened patients, 6597 had a total of 8892 clinically significant <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> alloantibodies identified, with 75% being in the Rh or Kell families. Alloimmunization was more common in females (2\u00b738%) than males (1\u00b768%), and in RhD negative (2\u00b782%) than RhD positive (1\u00b794%) patients. Age, sex, RhD status and race were associated with being a responder, and certain diagnoses (including sickle cell disease or trait, systemic lupus erythematosus, rheumatoid arthritis and myelodysplastic syndrome) were more common among responders than non\u2010responders. Data collected in this multi\u2010centre recipient database provide the largest <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> alloimmunized patient cohort studied in the <jats:styled-content style=\"fixed-case\">US<\/jats:styled-content>, with previously known demographic and disease associations of responder status confirmed, and new associations identified.<\/jats:p>","DOI":"10.1111\/bjh.15182","type":"journal-article","created":{"date-parts":[[2018,4,20]],"date-time":"2018-04-20T02:50:14Z","timestamp":1524192614000},"page":"672-681","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Risk factors for red blood cell alloimmunization in the Recipient Epidemiology and Donor Evaluation Study (<scp>REDS<\/scp>\u2010<scp>III<\/scp>) database"],"prefix":"10.1111","volume":"181","author":[{"given":"Matthew S.","family":"Karafin","sequence":"first","affiliation":[{"name":"Blood Center of Wisconsin Milwaukee WI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matt","family":"Westlake","sequence":"additional","affiliation":[{"name":"RTI International Rockville MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald G.","family":"Hauser","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University New Haven CT USA"},{"name":"VA CT West Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1785-2245","authenticated-orcid":false,"given":"Christopher A.","family":"Tormey","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University New Haven CT USA"},{"name":"VA CT West Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[{"name":"University of California San Francisco CA USA"},{"name":"Blood Systems Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nareg H.","family":"Roubinian","sequence":"additional","affiliation":[{"name":"University of California San Francisco CA USA"},{"name":"Blood Systems Research Institute San Francisco CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University New Haven CT USA"},{"name":"Bloodworks Northwest Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darrell J.","family":"Triulzi","sequence":"additional","affiliation":[{"name":"University of Pittsburgh and Institute of Transfusion Medicine Pittsburgh PA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kleinman","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7928-3132","authenticated-orcid":false,"given":"Jeanne E.","family":"Hendrickson","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine Yale University New Haven CT USA"},{"name":"Department of Pediatrics Yale University New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"NHLBI Recipient Epidemiology and Donor Evaluation Study\u2010III (REDS\u2010III)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,4,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/03630269.2015.1077460"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2016.01.011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-03-490623"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002795"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.13977"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-6247.137438"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2016.152074"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700401"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/trf.14288"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tmrv.2016.05.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-03-146415"},{"key":"e_1_2_8_13_1","first-page":"42","article-title":"Multiple red cell transfusions and alloimmunization. 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