{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:20:48Z","timestamp":1780471248792,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,4,10]],"date-time":"2018-04-10T00:00:00Z","timestamp":1523318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81301959"],"award-info":[{"award-number":["No. 81301959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["No. 81520108025"],"award-info":[{"award-number":["No. 81520108025"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,5]]},"abstract":"Abstract<\/jats:title>T cells modified with anti\u2010CD<\/jats:styled-content>19 chimeric antigen receptor (CAR<\/jats:styled-content>) containing either CD<\/jats:styled-content>28 or 4\u20101BB<\/jats:styled-content> (also termed TNFRSF<\/jats:styled-content>9, CD<\/jats:styled-content>137) costimulatory signalling have shown great potential in the treatment of acute lymphoblastic leukaemia (ALL<\/jats:styled-content>). However, the difference between CD<\/jats:styled-content>28 and 4\u20101BB<\/jats:styled-content> costimulatory signalling in CAR<\/jats:styled-content>\u2010T treatment has not been well elucidated in clinical trials. In this study, we treated 10 relapsed or refractory ALL<\/jats:styled-content> patients with the second generation CD<\/jats:styled-content>19 CAR<\/jats:styled-content>\u2010T. The first 5 patients were treated with CD<\/jats:styled-content>28\u2010CAR<\/jats:styled-content> and the other 5 patients were treated with 4\u20101BB CAR<\/jats:styled-content>\u2010T. All the 10 patients were response\u2010evaluable. Three patients achieved complete remission and 1 patient with extramedullary disease achieved partial response after CD<\/jats:styled-content>28\u2010CAR<\/jats:styled-content>\u2010T treatment. In the 4\u20101BB CAR<\/jats:styled-content>\u2010T treatment group, 3 patients achieved complete remission. Furthermore, FLT<\/jats:styled-content>\u20103 ligand (FLT<\/jats:styled-content>3LG<\/jats:styled-content>) was highly correlated with response time and may serve as a prognosis factor. No severe adverse events were observed in these 10 treated patients. Our study showed that both CD<\/jats:styled-content>28 CAR<\/jats:styled-content>\u2010T and 4\u20101BB CAR<\/jats:styled-content>\u2010T both worked for response but they differed in response pattern (peak reaction time, reaction lasting time and reaction degree), adverse events, cytokine secretion and immune\u2010suppressive factor level.<\/jats:p>","DOI":"10.1111\/bjh.15195","type":"journal-article","created":{"date-parts":[[2018,4,11]],"date-time":"2018-04-11T01:11:47Z","timestamp":1523409107000},"page":"360-371","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Treatment of acute lymphoblastic leukaemia with the second generation of CD<\/scp>19 CAR<\/scp>\u2010T containing either CD<\/scp>28 or 4\u20101BB<\/scp>"],"prefix":"10.1111","volume":"181","author":[{"given":"Shiqi","family":"Li","sequence":"first","affiliation":[{"name":"Centre of Biological Therapy Southwest Hospital Third Military Medical University 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