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With the exception of Down syndrome\u2010associated transient abnormal myelopoiesis, which is not considered here, neonatal leukaemias are rare. In two\u2010thirds of patients the disease manifests as an acute myeloid leukaemia, frequently with monocytic\/monoblastic characteristics. Most other cases are acute lymphoblastic leukaemia, particularly B lineage, but some are mixed phenotype or blastic plasmacytoid dendritic cell neoplasms. The most frequently observed cytogenetic\/molecular abnormality is t(4;11)(q21.3;q23.3)\/\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">KMT<\/jats:styled-content>\n                      2A\u2010\n                      <jats:styled-content style=\"fixed-case\">AFF<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    followed by t(1;22)(p13.3;q13.1)\/\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">RBM<\/jats:styled-content>\n                      15\u2010\n                      <jats:styled-content style=\"fixed-case\">MKL<\/jats:styled-content>\n                      1\n                    <\/jats:italic>\n                    and t(8;16)(p11.2;p13.3)\/\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">KAT<\/jats:styled-content>\n                      6A\u2010\n                      <jats:styled-content style=\"fixed-case\">CREBBP<\/jats:styled-content>\n                    <\/jats:italic>\n                    . Common clinical features include prominent hepatosplenomegaly and a high incidence of skin involvement, sometimes in the absence of bone marrow disease. A distinctive feature is the occurrence of spontaneous remission in some cases, particularly in association with t(8;16). In this review, we summarise current knowledge of the clinical, cytogenetic and molecular features of neonatal leukaemia and discuss clinical management of these cases.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15246","type":"journal-article","created":{"date-parts":[[2018,5,28]],"date-time":"2018-05-28T06:20:50Z","timestamp":1527488450000},"page":"170-184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":81,"title":["Neonatal leukaemia"],"prefix":"10.1111","volume":"182","author":[{"given":"Irene","family":"Roberts","sequence":"first","affiliation":[{"name":"MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine University of Oxford, Centre for Haematology Oxford UK"},{"name":"Oxford BRC Blood Theme, NIHR Oxford Biomedical Centre Oxford UK"},{"name":"Department of Paediatrics University of Oxford John Radcliffe Hospital Oxford 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