{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:45:36Z","timestamp":1787013936180,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T00:00:00Z","timestamp":1524096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007386","name":"Fondazione Cassa di Risparmio di Modena","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007386","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010824","name":"Associazione Angela Serra per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010824","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010299","name":"Allos Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010299","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Different models to investigate the prognosis of peripheral T cell lymphoma not otherwise specified (PTCL\u2010NOS) have been developed by means of retrospective analyses. Here we report on a new model designed on data from the prospective T Cell Project. Twelve covariates collected by the T Cell Project were analysed and a new model (T cell score), based on four covariates (serum albumin, performance status, stage and absolute neutrophil count) that maintained their prognostic value in multiple Cox proportional hazards regression analysis was proposed. Among patients registered in the T Cell Project, 311 PTCL\u2010NOS were retained for study. At a median follow\u2010up of 46\u00a0months, the median overall survival (OS) and progression\u2010free survival (PFS) was 20 and 10\u00a0months, respectively. Three groups were identified at low risk (LR, 48 patients, 15%, score 0), intermediate risk (IR, 189 patients, 61%, score 1\u20132), and high risk (HiR, 74 patients, 24%, score 3\u20134), having a 3\u2010year OS of 76% [95% confidence interval 61\u201388], 43% [35\u201351], and 11% [4\u201321], respectively (\n                    <jats:italic>P<\/jats:italic>\n                    \u00a0&lt;\u00a00\u00b7001). Comparing the performance of the T cell score on OS to that of each of the previously developed models, it emerged that the new score had the best discriminant power. The new T cell score, based on clinical variables, identifies a group with very unfavourable outcomes.\n                  <\/jats:p>","DOI":"10.1111\/bjh.15258","type":"journal-article","created":{"date-parts":[[2018,4,19]],"date-time":"2018-04-19T13:08:29Z","timestamp":1524143309000},"page":"760-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Peripheral T cell lymphoma, not otherwise specified (PTCL\u2010NOS). A new prognostic model developed by the International T cell Project Network"],"prefix":"10.1111","volume":"181","author":[{"given":"Massimo","family":"Federico","sequence":"first","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7846-732X","authenticated-orcid":false,"given":"Monica","family":"Bellei","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Marcheselli","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Schwartz","sequence":"additional","affiliation":[{"name":"MedNet Solutions Minnetonka MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Manni","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-0566","authenticated-orcid":false,"given":"Vittoria","family":"Tarantino","sequence":"additional","affiliation":[{"name":"Department of Diagnostic, Clinical and Public Health Medicine University of Modena and Reggio Emilia Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pileri","sequence":"additional","affiliation":[{"name":"IEO \u2013 Istituto Europeo di Oncologia Unit\u00e0 di Diagnosi Emolinfopatologica Milano Italy"},{"name":"Universit\u00e0 degli Studi di Bologna, Scuola di Medicina e Chirurgia Alma mater Professor of Pathology Bologna Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young\u2010Hyeh","family":"Ko","sequence":"additional","affiliation":[{"name":"Department of Pathology Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Cabrera","sequence":"additional","affiliation":[{"name":"Hospital del Salvador Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Horwitz","sequence":"additional","affiliation":[{"name":"Memorial Sloan\u2010Kettering Cancer Center New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Won S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Haematology\u2010Oncology Samsung Medical Centre Sungkyunkwan University School of Medicine Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei","family":"Shustov","sequence":"additional","affiliation":[{"name":"Fred Hutchinson Cancer Research Center Seattle WA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francine M.","family":"Foss","sequence":"additional","affiliation":[{"name":"Yale University School of Medicine New Haven CT USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnon","family":"Nagler","sequence":"additional","affiliation":[{"name":"Sheba Medical Centre Tel Hashomer Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Carson","sequence":"additional","affiliation":[{"name":"Washington University School of Medicine St. Louis MO USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren C.","family":"Pinter\u2010Brown","sequence":"additional","affiliation":[{"name":"UCI Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Montoto","sequence":"additional","affiliation":[{"name":"Department of Haemato\u2010Oncology St. Bartholomew's Hospital Barts Health NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Spina","sequence":"additional","affiliation":[{"name":"Medical Oncology A National Cancer Institute Aviano Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana A.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Hackensack University Medical Center Hackensack NJ USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary J.","family":"Lechowicz","sequence":"additional","affiliation":[{"name":"Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonali M.","family":"Smith","sequence":"additional","affiliation":[{"name":"University of Chicago Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Lansigan","sequence":"additional","affiliation":[{"name":"Dartmouth Hitchcock Medical Center Hanover NH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul","family":"Gabus","sequence":"additional","affiliation":[{"name":"Service of Haematology and Bone Marrow Transplantation Hospital Maciel Montevideo Uruguay"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie M.","family":"Vose","sequence":"additional","affiliation":[{"name":"University of Nebraska Medical Center UNMC, Internal Medicine Omaha NE USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjana H.","family":"Advani","sequence":"additional","affiliation":[{"name":"Stanford University Medical Center Stanford CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the T cell Project 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