{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:47:30Z","timestamp":1790416050375,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Treatment of Burkitt lymphoma (<jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>) with intensive, multi\u2010agent chemotherapy with aggressive central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) prophylaxis results in high cure rates, although no regimen is standard of care. We examined population\u2010based survival outcomes of adults with <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> treated with a modified combination of cyclophosphamide, vincristine, doxorubicin, prednisone and systemic high\u2010dose methotrexate (<jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">CODOX<\/jats:styled-content>\u2010M) with <jats:styled-content style=\"fixed-case\">IVAC<\/jats:styled-content> (ifosfamide, mesna, etoposide, cytarabine and intrathecal <jats:styled-content style=\"fixed-case\">MTX<\/jats:styled-content>) (<jats:styled-content style=\"fixed-case\">CODOX<\/jats:styled-content>\u2010M\/<jats:styled-content style=\"fixed-case\">IVAC<\/jats:styled-content>) \u00b1 rituximab over a 15\u2010year period in British Columbia. For the 81 patients identified (including 8 with <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement and 18 with human immunodeficiency virus\u2010associated <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content>), 5\u2010year progression\u2010free survival (<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>) and overall survival (<jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content>) were 75% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>): 63\u201383%] and 77% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>: 66\u201385%), respectively, with no treatment\u2010related deaths. Those who completed the regimen per protocol (<jats:italic>n<\/jats:italic>\u00a0=\u00a038) had significantly improved 5\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> 86% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b704) and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> 92% (<jats:italic>P\u00a0<\/jats:italic>=\u00a00\u00b7008), as did those under 60\u00a0years with 5\u2010year <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content> 82% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7005) and <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> 86% (<jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7002), which remained significant in multivariate analysis [<jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>: hazard ratio (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) 3\u00b736, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7018; <jats:styled-content style=\"fixed-case\">OS HR<\/jats:styled-content> 4\u00b703, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7012]. Incorporation of high\u2010dose systemic methotrexate also significantly affected multivariate survival outcomes (<jats:styled-content style=\"fixed-case\">OS HR<\/jats:styled-content> 0\u00b728, <jats:italic>P<\/jats:italic>\u00a0=\u00a00\u00b7025). Stem cell transplant in first remission had no effect on <jats:styled-content style=\"fixed-case\">OS<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">PFS<\/jats:styled-content>. This large, real\u2010world analysis of <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> patients treated with <jats:styled-content style=\"fixed-case\">CODOX<\/jats:styled-content>\u2010M\/<jats:styled-content style=\"fixed-case\">IVAC<\/jats:styled-content> \u00b1 rituximab demonstrates excellent survival outcomes comparable to clinical trials. These results help to serve as a benchmark when comparing curative therapies for <jats:styled-content style=\"fixed-case\">BL<\/jats:styled-content> patients as novel regimens are incorporated into clinical practice.<\/jats:p>","DOI":"10.1111\/bjh.15262","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T16:28:34Z","timestamp":1525883314000},"page":"782-790","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Excellent real\u2010world outcomes of adults with Burkitt lymphoma treated with <scp>CODOX<\/scp>\u2010M\/<scp>IVAC<\/scp> plus or minus rituximab"],"prefix":"10.1111","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9994-3409","authenticated-orcid":false,"given":"Katie Y.","family":"Zhu","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin W.","family":"Song","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph M.","family":"Connors","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer BC Cancer Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Leitch","sequence":"additional","affiliation":[{"name":"Division of Hematology St. Paul's Hospital University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Barnett","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Division of Hematology St. Paul's Hospital University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham W.","family":"Slack","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser","family":"Abou Mourad","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna L.","family":"Forrest","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna E.","family":"Hogge","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen H.","family":"Nantel","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujaatha","family":"Narayanan","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Nevill","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryse M.","family":"Power","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Sanford","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather J.","family":"Sutherland","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracy","family":"Tucker","sequence":"additional","affiliation":[{"name":"Genetics Laboratory BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia L.","family":"Toze","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie H.","family":"Sehn","sequence":"additional","affiliation":[{"name":"Centre for Lymphoid Cancer BC Cancer Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raewyn","family":"Broady","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina S.","family":"Gerrie","sequence":"additional","affiliation":[{"name":"Hematology Leukemia\/BMT Program of BC BC Cancer University of British Columbia Vancouver BC Canada"},{"name":"Centre for Lymphoid Cancer BC Cancer Vancouver BC 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