{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:51:52Z","timestamp":1791244312406,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T00:00:00Z","timestamp":1526428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008322","name":"CSL Behring","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,7]]},"abstract":"Summary<\/jats:title>Some comorbidities, such as hypertension, are associated with higher von Willebrand factor (VWF<\/jats:styled-content>) levels in the general population. No studies have been conducted to assess this association in patients with von Willebrand disease (VWD<\/jats:styled-content>). Therefore, we studied this association in patients with type 1 (n<\/jats:italic>\u00a0=\u00a0333) and type 2 (n<\/jats:italic>\u00a0=\u00a0203) VWD<\/jats:styled-content> from the \u2018WiN\u201d study. VWF<\/jats:styled-content> antigen (VWF<\/jats:styled-content>:Ag) was higher in type 1 VWD<\/jats:styled-content> patients with hypertension [difference: 0\u00b723\u00a0iu\/ml, 95% confidence interval (CI<\/jats:styled-content>): 0\u00b711\u20130\u00b735], diabetes mellitus (0\u00b711\u00a0iu\/ml, 95% CI<\/jats:styled-content>: \u22120\u00b702 to 0\u00b723), cancer (0\u00b714\u00a0iu\/ml, 95% CI<\/jats:styled-content>: 0\u00b703\u20130\u00b725) and thyroid dysfunction (0\u00b714\u00a0iu\/ml, 95% CI<\/jats:styled-content>: 0\u00b703\u20130\u00b726) than in patients without these comorbidities (all corrected for age, sex and blood group). Similar results were observed for VWF<\/jats:styled-content> collagen binding capacity (VWF<\/jats:styled-content>:CB<\/jats:styled-content>), VWF<\/jats:styled-content> activity as measured by the VWF<\/jats:styled-content> monoclonal antibody assay (VWF<\/jats:styled-content>:Ab) and factor VIII<\/jats:styled-content> (FVIII<\/jats:styled-content>) coagulant activity (FVIII<\/jats:styled-content>:C). In type 1 VWD<\/jats:styled-content>, age was associated with higher VWF<\/jats:styled-content>:Ag (0\u00b703\u00a0iu\/ml; 95% CI<\/jats:styled-content>: 0\u00b701\u20130\u00b704), VWF<\/jats:styled-content>:CB<\/jats:styled-content> (0\u00b702\u00a0iu\/ml; 95% CI<\/jats:styled-content>: 0\u00b700\u20130\u00b704), VWF<\/jats:styled-content>:Ab (0\u00b704\u00a0iu\/ml; 95% CI<\/jats:styled-content>: 0\u00b702\u20130\u00b706) and FVIII<\/jats:styled-content>:C (0\u00b703\u00a0iu\/ml; 95% CI<\/jats:styled-content>: 0\u00b701\u20130\u00b706) per decade increase. After adjustment for relevant comorbidities, these associations were no longer significant. Despite the higher VWF<\/jats:styled-content> and FVIII<\/jats:styled-content> levels, type 1 VWD<\/jats:styled-content> patients with comorbidities had more bleeding episodes, particularly during surgery. There was no association between comorbidities and VWF<\/jats:styled-content>\/FVIII<\/jats:styled-content> levels or bleeding phenotype in type 2 VWD<\/jats:styled-content> patients. In conclusion, comorbidities are associated with higher VWF<\/jats:styled-content> and FVIII<\/jats:styled-content> levels in type 1 VWD<\/jats:styled-content> and may explain the age\u2010related increase of VWF<\/jats:styled-content> and FVIII<\/jats:styled-content> levels.<\/jats:p>","DOI":"10.1111\/bjh.15277","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T13:00:19Z","timestamp":1526475619000},"page":"93-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Comorbidities associated with higher von Willebrand factor (VWF<\/scp>) levels may explain the age\u2010related increase of VWF<\/scp> in von Willebrand disease"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3769-9148","authenticated-orcid":false,"given":"Ferdows","family":"Atiq","sequence":"first","affiliation":[{"name":"Department of Haematology Erasmus University Medical Centre Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Meijer","sequence":"additional","affiliation":[{"name":"Department of Haematology University of Groningen University Medical Centre Groningen Groningen the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Eikenboom","sequence":"additional","affiliation":[{"name":"Department of Thrombosis and Haemostasis Leiden University Medical Centre Leiden the Netherlands"},{"name":"Einthoven Laboratory for Vascular and Regenerative Medicine Leiden University Medical Centre Leiden the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Fijnvandraat","sequence":"additional","affiliation":[{"name":"Pediatric Haematology Emma Children's Hospital\u2010Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eveline P.","family":"Mauser\u2010Bunschoten","sequence":"additional","affiliation":[{"name":"Van Creveldkliniek University Medical Centre University Utrecht Utrecht the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3251-8595","authenticated-orcid":false,"given":"Karin P. 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