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Once diagnosed, affected patients should be referred to a specialist centre for bleeding disorders for general advice and ongoing management. Patients do not require prophylactic treatment and so the management of <jats:styled-content style=\"fixed-case\">GT<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">BSS<\/jats:styled-content> focuses around prophylactic treatment prior to high risk procedures and treatment in response to non\u2010surgical bleeding events and, in women, the management of menorrhagia and pregnancy. There is no consistent approach to the treatment or prevention of bleeding complications. Management must be tailored for each individual and the approach may not be the same for different events, even for the same patient, depending on the type of accident or invasive procedure, the extent of bleeding and the presence or not of platelet refractoriness.<\/jats:p>","DOI":"10.1111\/bjh.15409","type":"journal-article","created":{"date-parts":[[2018,8,17]],"date-time":"2018-08-17T09:45:15Z","timestamp":1534499115000},"page":"621-632","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":93,"title":["How we treat the platelet glycoprotein defects; Glanzmann thrombasthenia and Bernard Soulier syndrome in children and adults"],"prefix":"10.1111","volume":"182","author":[{"given":"John D.","family":"Grainger","sequence":"first","affiliation":[{"name":"Faculty of Medical &amp; Human Sciences University of Manchester England UK"},{"name":"Department of Paediatric Haematology Royal Manchester Children's Hospital Manchester 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