{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T19:03:03Z","timestamp":1790276583236,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,5]],"date-time":"2018-06-05T00:00:00Z","timestamp":1528156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006483","name":"AbbVie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006483","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Patients with chronic lymphocytic leukaemia\/small lymphocytic lymphoma (<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>) with deletion 17p [del(17p)] have poor outcomes with chemoimmunotherapy. Ibrutinib is indicated for the treatment of <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>, including del(17p) <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>, and allows for treatment without chemotherapy. This integrated analysis was performed to evaluate outcomes in 230 patients with relapsed\/refractory del(17p) <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content> from three ibrutinib studies. With a median of 2 prior therapies (range, 1\u201312), 18% and 79% of evaluable patients had del(11q) or unmutated <jats:italic><jats:styled-content style=\"fixed-case\">IGHV<\/jats:styled-content><\/jats:italic>, respectively. With a median follow\u2010up of 28\u00a0months, overall response rate was 85% and estimated 30\u2010month progression\u2010free and overall survival rates were 57% [95% confidence interval (<jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content>) 50\u201364] and 69% (95% <jats:styled-content style=\"fixed-case\">CI<\/jats:styled-content> 61\u201375), respectively. Patients with normal lactate dehydrogenase or no bulky disease had the most favourable survival outcomes. Sustained haematological improvements in haemoglobin, platelet count and absolute neutrophil count occurred in 61%, 67% and 70% of patients with baseline cytopenias, respectively. New onset severe cytopenias and infections decreased in frequency over time. Progression\u2010free and overall survival with ibrutinib surpass those of other therapies for patients with del(17p) <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content>. These results provide further evidence of the robust clinical activity of ibrutinib in difficult\u2010to\u2010treat <jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>\/<jats:styled-content style=\"fixed-case\">SLL<\/jats:styled-content> populations.<\/jats:p>","DOI":"10.1111\/bjh.15421","type":"journal-article","created":{"date-parts":[[2018,6,6]],"date-time":"2018-06-06T04:22:08Z","timestamp":1528258928000},"page":"504-512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Evaluation of 230 patients with relapsed\/refractory deletion 17p chronic lymphocytic\u00a0leukaemia treated with ibrutinib from 3 clinical trials"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9557-0820","authenticated-orcid":false,"given":"Jeffrey","family":"Jones","sequence":"first","affiliation":[{"name":"Ohio State University Comprehensive Cancer Center Columbus OH 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