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A total of 19 uncommon transcripts, including e1a2, e1a3, e6a2, e8a2, e12a2, unusual e13a2, e13a3, unusual e14a2, e14a3 and e19a2 were identified in 83 (1\u00b77%) patients. The three most frequent types were e19a2, e13a3\/e14a3 and e1a2. Compared with the 571 newly diagnosed <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> patients in chronic phase with common e13a2\/e14a2 transcripts receiving frontline imatinib therapy, patients with the e19a2 (<jats:italic>n\u00a0=\u00a0<\/jats:italic>16) and e1a2 (<jats:italic>n\u00a0=\u00a0<\/jats:italic>11) transcripts had significantly reduced probabilities of 1\u2010year complete cytogenetic response (<jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>yR, <jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b70004 and 0\u00b7016) and major molecular response (<jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content>,<jats:italic> P\u00a0=\u00a0<\/jats:italic>0\u00b70018 and 0\u00b70035), and patients with the e13a3\/e14a3 transcript (<jats:italic>n\u00a0=\u00a0<\/jats:italic>10) had significantly increased probabilities of 1\u2010year <jats:styled-content style=\"fixed-case\">CC<\/jats:styled-content>yR (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b70072) and <jats:styled-content style=\"fixed-case\">MMR<\/jats:styled-content> (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b70073). Patients with the e19a2 transcript had low probabilities of 2\u2010year event\u2010free survival (<jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content>,<jats:italic> P\u00a0=\u00a0<\/jats:italic>0\u00b70004) and progression\u2010free survival (<jats:italic>P\u00a0=\u00a0<\/jats:italic>0\u00b70067), and patients with the e1a2 transcript had low probability of 2\u2010year <jats:styled-content style=\"fixed-case\">EFS<\/jats:styled-content> (<jats:italic>P\u00a0<\/jats:italic>&lt;<jats:italic>\u00a0<\/jats:italic>0\u00b70001). Therefore, uncommon <jats:italic><jats:styled-content style=\"fixed-case\">BCR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">ABL<\/jats:styled-content>1<\/jats:italic> fusion transcripts are rare and diverse in patients with <jats:styled-content style=\"fixed-case\">CML<\/jats:styled-content> and may be relevant for <jats:styled-content style=\"fixed-case\">TKI<\/jats:styled-content> therapy outcomes.<\/jats:p>","DOI":"10.1111\/bjh.15453","type":"journal-article","created":{"date-parts":[[2018,7,5]],"date-time":"2018-07-05T12:05:00Z","timestamp":1530792300000},"page":"693-700","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":46,"title":["Prevalence and outcomes of uncommon <i><scp>BCR<\/scp>\u2010<scp>ABL<\/scp>1<\/i> fusion transcripts in patients with chronic myeloid leukaemia: data from a single centre"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1548-0946","authenticated-orcid":false,"given":"Ya\u2010Zhen","family":"Qin","sequence":"first","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Haematology Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7131-0522","authenticated-orcid":false,"given":"Qian","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Haematology Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation Beijing China"},{"name":"Collaborative Innovation Centre of Haematology Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Haematology Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue\u2010Yun","family":"Lai","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Haematology Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Xia","family":"Shi","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Haematology Beijing Key Laboratory of Haematopoietic Stem Cell Transplantation Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Min","family":"Chen","sequence":"additional","affiliation":[{"name":"Peking University People's Hospital Peking University Institute of Haematology Beijing Key Laboratory of Haematopoietic 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