{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:02:09Z","timestamp":1792087329972,"version":"4.4.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006436","name":"Celgene","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010795","name":"Chugai Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010795","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["G0100132"],"award-info":[{"award-number":["G0100132"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007110","name":"Schering-Plough","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007110","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>In the Medical Research Council (<jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content>) Myeloma <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> trial (<jats:styled-content style=\"fixed-case\">ISRCTN<\/jats:styled-content>684564111) patients were randomised to sodium clodronate or zoledronic acid and induction treatment: cyclophosphamide, vincristine, doxorubicin and dexamethasone (<jats:styled-content style=\"fixed-case\">CVAD<\/jats:styled-content>) or cyclophosphamide, thalidomide and dexamethasone (<jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>) followed by autologous stem cell transplant (<jats:styled-content style=\"fixed-case\">ASCT<\/jats:styled-content>) in the intensive pathway; attenuated <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> or melphalan and prednisolone (<jats:styled-content style=\"fixed-case\">MP<\/jats:styled-content>) in the non\u2010intensive pathway. Subsequent randomisation allocated patients to either thalidomide or observation. The European Organisation for Research and Treatment of Cancer (<jats:styled-content style=\"fixed-case\">EORTC<\/jats:styled-content>) quality of life (QoL) questionnaires, <jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010C30 and <jats:styled-content style=\"fixed-case\">QLQ<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MY<\/jats:styled-content>24, were administered at baseline, 3, 6 and 12\u00a0months and annually thereafter, enabling the effect of sequential treatment on patient\u2010reported health\u2010related QoL (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010QoL) to be investigated. The protocol specified four subscales of interest: Pain, Fatigue, Global Health Status\/Quality of Life and Physical Functioning at 3, 6 and 12\u00a0months that were compared using linear models. The intensive pathway showed significant differences in favour of <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content> for Fatigue at 3\u00a0months and Physical Functioning at 12\u00a0months. The non\u2010intensive pathway and maintenance phase reported significant differences at 3\u00a0months; Pain (improved with attenuated <jats:styled-content style=\"fixed-case\">CTD<\/jats:styled-content>) and Global Health status\/Quality of Life (improved with observation). The improved outcomes in <jats:styled-content style=\"fixed-case\">MRC<\/jats:styled-content> Myeloma <jats:styled-content style=\"fixed-case\">IX<\/jats:styled-content> were accompanied by some beneficial and few detrimental effects on <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010QoL.<\/jats:p>","DOI":"10.1111\/bjh.15459","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T10:58:27Z","timestamp":1531133907000},"page":"816-829","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Quality of life during and following sequential treatment of previously untreated patients with multiple myeloma: findings of the Medical Research Council Myeloma <scp>IX<\/scp> randomised study"],"prefix":"10.1111","volume":"182","author":[{"given":"Kara\u2010Louise","family":"Royle","sequence":"first","affiliation":[{"name":"CTRU University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter M.","family":"Gregory","sequence":"additional","affiliation":[{"name":"CTRU University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2338-0179","authenticated-orcid":false,"given":"David A.","family":"Cairns","sequence":"additional","affiliation":[{"name":"CTRU University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue E.","family":"Bell","sequence":"additional","affiliation":[{"name":"CTRU University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon","family":"Cook","sequence":"additional","affiliation":[{"name":"LICAP University of Leeds Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger G.","family":"Owen","sequence":"additional","affiliation":[{"name":"HMDS St James's University Hospital Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark T.","family":"Drayson","sequence":"additional","affiliation":[{"name":"Clinical Immunology Service University of Birmingham Birmingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faith E.","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research Sutton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham H.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Northern Cancer Centre Newcastle University Newcastle\u2010upon\u2010Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth J.","family":"Morgan","sequence":"additional","affiliation":[{"name":"Institute of Cancer Research Sutton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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