{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:33:46Z","timestamp":1790696026550,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T00:00:00Z","timestamp":1531440000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Br J Haematol"],"published-print":{"date-parts":[[2018,9]]},"abstract":"Summary<\/jats:title>Isolated trisomy 8 (+8) is a frequent cytogenetic abnormality in the myelodysplastic syndromes (MDS<\/jats:styled-content>), but its characteristics are poorly reported. We performed a retrospective study of 138 MDS<\/jats:styled-content> patients with isolated +8, classified or reclassified as MDS<\/jats:styled-content> (excluding MDS<\/jats:styled-content>\/myeloproliferative neoplasm). Myeloproliferative (MP<\/jats:styled-content>) features were defined by the repeated presence of one of the following: white blood cell count >10\u00a0\u00d7\u00a0109<\/jats:sup>\/l, myelemia (presence of circulating immature granulocytes with a predominance of more mature forms) >2%, palpable splenomegaly. Fifty\u2010four patients (39\u00b71%) had MP<\/jats:styled-content> features: 28 at diagnosis, 26 were acquired during evolution. MP<\/jats:styled-content> forms had more EZH<\/jats:styled-content>2<\/jats:italic> (33\u00b73% vs. 12\u00b70% in non\u2010MP<\/jats:styled-content>, P<\/jats:italic>\u00a0=\u00a00\u00b7047), ASXL<\/jats:styled-content>1<\/jats:italic> (66\u00b77% vs. 42\u00b73%, P<\/jats:italic>\u00a0=\u00a00\u00b7048) and STAG<\/jats:styled-content>2<\/jats:italic> mutations (77\u00b78% vs. 21\u00b77%, P<\/jats:italic>\u00a0=\u00a00\u00b7006). Median event\u2010free survival (EFS) and overall survival (OS<\/jats:styled-content>) were 25 and 27\u00a0months for patients with MP<\/jats:styled-content> features at diagnosis, versus<\/jats:italic> 28 (P<\/jats:italic>\u00a0=\u00a00\u00b715) and 39\u00a0months (P<\/jats:italic>\u00a0=\u00a00\u00b7085) for those without MP<\/jats:styled-content> features, respectively. Among the 57 patients who received hypomethylating agent (HMA<\/jats:styled-content>), OS<\/jats:styled-content> was lower in MP<\/jats:styled-content> cases (13\u00a0months vs. 23\u00a0months in non\u2010MP<\/jats:styled-content> cases, P<\/jats:italic>\u00a0=\u00a00.02). In conclusion, MP<\/jats:styled-content> features are frequent in MDS<\/jats:styled-content> with isolated +8. MP<\/jats:styled-content> forms had more EZH<\/jats:styled-content>2<\/jats:italic>, ASXL<\/jats:styled-content>1<\/jats:italic> and STAG<\/jats:styled-content>2<\/jats:italic> mutations, responded poorly to HMA<\/jats:styled-content>, and tended to have poorer survival than non\u2010MP<\/jats:styled-content> forms.<\/jats:p>","DOI":"10.1111\/bjh.15490","type":"journal-article","created":{"date-parts":[[2018,7,13]],"date-time":"2018-07-13T13:55:33Z","timestamp":1531490133000},"page":"843-850","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Myelodysplastic syndrome (MDS<\/scp>) with isolated trisomy 8: a type of MDS<\/scp> frequently associated with myeloproliferative features? A report by the Groupe Francophone des My\u00e9lodysplasies"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-0380","authenticated-orcid":false,"given":"Louis","family":"Drevon","sequence":"first","affiliation":[{"name":"H\u00f4pital Saint\u2010Louis Assistance Publique H\u00f4pitaux de Paris (APHP) University Paris Diderot (Paris 7) Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Marceau","sequence":"additional","affiliation":[{"name":"Centre Hospitalier R\u00e9gional Universitaire (CHRU) de Lille Lille France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odile","family":"Maarek","sequence":"additional","affiliation":[{"name":"H\u00f4pital Saint\u2010Louis Assistance Publique H\u00f4pitaux de Paris (APHP) University Paris Diderot (Paris 7) Paris 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